| Gene Symbol |
CDC42SE1
|
| Entrez Gene |
56882
|
| Alt Symbol |
SCIP1, SPEC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC42 small effector 1
|
| Other Description |
1300002M12Rik|CDC42 small effector protein 1|CDC42-binding protein SCIP1|signaling molecule SPEC1 beta|small effector of CDC42 protein 1|small protein effector 1 of Cdc42
|
| Swissprots |
Q9NRR8 Q9NQR2 Q9HB17 D3DV12
|
| Accessions |
EAW53477 EAW53478 EAW53479 Q9NRR8 AF187845 AAF87597 AF286041 AAF97248 AF286592 AAG17723 AK054914 BC012796 AAH12796 BC041604 AAH41604 BP340339 BX339337 DQ894194 ABM85120 NM_001038707 NP_001033796 NM_020239 NP_064624
|
| Function |
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583, ECO:0000269|PubMed:17045588}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in T-lymphocytes, dendritic and whole blood cells. {ECO:0000269|PubMed:15840583}.
|
