Gene Symbol | ASRGL1 |
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Entrez Gene | 80150 |
Alt Symbol | ALP, ALP1, CRASH |
Species | Human |
Gene Type | protein-coding |
Description | asparaginase like 1 |
Other Description | L-asparaginase|L-asparagine amidohydrolase|asparaginase-like 1 protein|asparaginase-like protein 1|beta-aspartyl-peptidase|isoaspartyl dipeptidase|isoaspartyl peptidase/L-asparaginase |
Swissprots | Q8NI34 Q9H6F7 B2R7Q0 Q6P1P0 Q567Q4 Q7L266 |
Accessions | EAW74012 EAW74013 EAW74014 EAW74015 EAW74016 EAW74017 Q7L266 AF411076 AAM28434 AK090908 BAG52245 AK091894 BAG52437 AK225802 AK297158 BAG59656 AK309845 AK313069 BAG35897 BC006267 AAH06267 BC021295 AAH21295 BC064963 AAH64963 BC093070 AAH93070 BP308677 BX640832 DA159051 DT220454 EU831759 ACE87277 EU831837 ACE86596 XM_005274304 XP_005274361 XM_005274305 XP_005274362 XM_005274306 XP_005274363 XM_011545264 XP_011543566 XM_011545265 XP_011543567 XM_011545266 XP_011543568 NM_001083926 NP_001077395 NM_025080 NP_079356 |
Function | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. {ECO:0000269|PubMed:19839645}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11984834}. Note=Midpiece of sperm tail. |
Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:14654938}. |
Human ASRGL1 full length protein - ab164205 from Abcam
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Human ASRGL1 full length protein - ab187483 from Abcam
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Human ASRGL1 protein fragment - ab164206 from Abcam
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ASRGL1 Antibody Blocking Peptide - LS-E19471 from LifeSpan Bioscience
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ASRGL1 Antibody Blocking Peptide - LS-E26511 from LifeSpan Bioscience
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ASRGL1 Recombinant Protein - H00080150-P01 from Novus Biologicals
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ASRGL1 Partial Recombinant Protein - H00080150-Q01 from Novus Biologicals
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Recombinant Bacterial L-Asparaginase Protein - NBP1-72323 from Novus Biologicals
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L-Asparaginase Recombinant Protein - P5008 from Novus Biologicals
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ASRGL1/ALP blocking peptide - GTX88848-PEP from GeneTex
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L-Asparaginase protein - orb90161 from Biorbyt
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Asrgl1 Blocking Peptide - 33R-1331 from Fitzgerald
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ASRGL1 Peptide - AC21-1348-P from Abcore
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L-asparaginase (1-308, His-tag) - AR51709PU-N from Acris Antibodies
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L-asparaginase (1-308, His-tag) - AR51709PU-S from Acris Antibodies
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L-asparaginase - H00080150-P01-10 from Acris Antibodies
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L-asparaginase - H00080150-P01-25 from Acris Antibodies
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L-asparaginase - H00080150-Q01-10 from Acris Antibodies
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L-asparaginase - H00080150-Q01-25 from Acris Antibodies
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ASRGL1 Peptide - 46-628P from ProSci
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ASRGL1 fusion protein - Ag1955 from Proteintech Group
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L-Asparaginase - ENPS-294 from NeoScientific
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L-Asparaginase - BP000672-ENZ-287 from Syd Labs
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L-Asparaginase - GWB-E463BB from Genway Biotech
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Recombinant Human Asparaginase Like 1 - ASRGL1-1841H from Creative Biomart
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