Gene Symbol | ASRGL1 |
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Entrez Gene | 80150 |
Alt Symbol | ALP, ALP1, CRASH |
Species | Human |
Gene Type | protein-coding |
Description | asparaginase like 1 |
Other Description | L-asparaginase|L-asparagine amidohydrolase|asparaginase-like 1 protein|asparaginase-like protein 1|beta-aspartyl-peptidase|isoaspartyl dipeptidase|isoaspartyl peptidase/L-asparaginase |
Swissprots | Q8NI34 Q9H6F7 B2R7Q0 Q6P1P0 Q567Q4 Q7L266 |
Accessions | EAW74012 EAW74013 EAW74014 EAW74015 EAW74016 EAW74017 Q7L266 AF411076 AAM28434 AK090908 BAG52245 AK091894 BAG52437 AK225802 AK297158 BAG59656 AK309845 AK313069 BAG35897 BC006267 AAH06267 BC021295 AAH21295 BC064963 AAH64963 BC093070 AAH93070 BP308677 BX640832 DA159051 DT220454 EU831759 ACE87277 EU831837 ACE86596 XM_005274304 XP_005274361 XM_005274305 XP_005274362 XM_005274306 XP_005274363 XM_011545264 XP_011543566 XM_011545265 XP_011543567 XM_011545266 XP_011543568 NM_001083926 NP_001077395 NM_025080 NP_079356 |
Function | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. {ECO:0000269|PubMed:19839645}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11984834}. Note=Midpiece of sperm tail. |
Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:14654938}. |
ASRGL1 (C-17) - sc-249971 from Santa Cruz Biotechnology
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ASRGL1 (N-17) - sc-249969 from Santa Cruz Biotechnology
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ASRGL1 (LA-52) - sc-130472 from Santa Cruz Biotechnology
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Anti-ASRGL1 antibody - ab150832 from Abcam
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Anti-ASRGL1 antibody - ab166949 from Abcam
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Anti-ASRGL1 antibody - ab168992 from Abcam
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Anti-ASRGL1 Antibody (clone 5C8) - LS-C133819 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody (Internal) - LS-C126898 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody - LS-C306413 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody - LS-C309537 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody - LS-C309539 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody (aa251-300) - LS-C135306 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody (aa2-180) - LS-C179179 from LifeSpan Bioscience
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Anti-ASRGL1 Antibody (Internal) - LS-C61707 from LifeSpan Bioscience
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ASRGL1 Antibody - NBP2-38759 from Novus Biologicals
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ASRGL1 Antibody - NBP1-89133 from Novus Biologicals
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L-Asparaginase Antibody - NBP1-78086 from Novus Biologicals
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ASRGL1 Antibody - NBP1-00155 from Novus Biologicals
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ASRGL1 Antibody - H00080150-B01P from Novus Biologicals
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ASRGL1 Antibody - H00080150-D01P from Novus Biologicals
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ASRGL1 Antibody - H00080150-B01 from Novus Biologicals
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ASRGL1 Antibody - H00080150-A01 from Novus Biologicals
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ASRGL1 Antibody - H00080150-D01 from Novus Biologicals
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ASRGL1 Antibody (5C8) - H00080150-M03A from Novus Biologicals
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Monoclonal Anti-ASRGL1 antibody produced in mouse - SAB1405282 from Sigma-Aldrich
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