ASRGL1
| Gene Symbol | ASRGL1 |
|---|---|
| Entrez Gene | 80150 |
| Alt Symbol | ALP, ALP1, CRASH |
| Species | Human |
| Gene Type | protein-coding |
| Description | asparaginase like 1 |
| Other Description | L-asparaginase|L-asparagine amidohydrolase|asparaginase-like 1 protein|asparaginase-like protein 1|beta-aspartyl-peptidase|isoaspartyl dipeptidase|isoaspartyl peptidase/L-asparaginase |
| Swissprots | Q8NI34 Q9H6F7 B2R7Q0 Q6P1P0 Q567Q4 Q7L266 |
| Accessions | EAW74012 EAW74013 EAW74014 EAW74015 EAW74016 EAW74017 Q7L266 AF411076 AAM28434 AK090908 BAG52245 AK091894 BAG52437 AK225802 AK297158 BAG59656 AK309845 AK313069 BAG35897 BC006267 AAH06267 BC021295 AAH21295 BC064963 AAH64963 BC093070 AAH93070 BP308677 BX640832 DA159051 DT220454 EU831759 ACE87277 EU831837 ACE86596 XM_005274304 XP_005274361 XM_005274305 XP_005274362 XM_005274306 XP_005274363 XM_011545264 XP_011543566 XM_011545265 XP_011543567 XM_011545266 XP_011543568 NM_001083926 NP_001077395 NM_025080 NP_079356 |
| Function | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. {ECO:0000269|PubMed:19839645}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11984834}. Note=Midpiece of sperm tail. |
| Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:14654938}. |
ASRGL1 CRISPR/Cas9 KO Plasmid (h) - sc-406195 from Santa Cruz Biotechnology
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ASRGL1 HDR Plasmid (h) - sc-406195-HDR from Santa Cruz Biotechnology
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ASRGL1 Double Nickase Plasmid (h) - sc-406195-NIC from Santa Cruz Biotechnology
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ASRGL1 Double Nickase Plasmid (h2) - sc-406195-NIC-2 from Santa Cruz Biotechnology
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ASRGL1 CRISPR Activation Plasmid (h) - sc-406195-ACT from Santa Cruz Biotechnology
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ASRGL1 CRISPR Activation Plasmid (h2) - sc-406195-ACT-2 from Santa Cruz Biotechnology
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ASRGL1 Lentiviral Activation Particles (h) - sc-406195-LAC from Santa Cruz Biotechnology
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ASRGL1 Lentiviral Activation Particles (h2) - sc-406195-LAC-2 from Santa Cruz Biotechnology
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ASRGL1 siRNA (h) - sc-96527 from Santa Cruz Biotechnology
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ASRGL1 shRNA Plasmid (h) - sc-96527-SH from Santa Cruz Biotechnology
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ASRGL1 shRNA (h) Lentiviral Particles - sc-96527-V from Santa Cruz Biotechnology
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ASRGL1 RNAi - H00080150-R02 from Novus Biologicals
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MISSION® esiRNA - EHU021161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3613 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3613 from Sigma-Aldrich
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ASRGL1 siRNA (Human) - CRJ2774 from Cohesion Biosciences
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ASRGL1 RNAi - H00080150-R01 from Novus Biologicals
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ASRGL1 - MBS827415 from MyBioSource
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shRNA set against Human ASRGL1 (NM_025080.3) - SHH241686 from Creative biogene
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shRNA set against Human ASRGL1(NM_001083926.1) - SHG078391 from Creative biogene
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ASRGL1 shRNA Plasmid (Human) - CHJ2774 from Cohesion Biosciences
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ASRGL1 miRNA 3'UTR clone - MiUTR1H-00643 from Creative biogene
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ASRGL1 miRNA 3'UTR clone - MiUTR3H-10484 from Creative biogene
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