HP

Gene Symbol HP
Entrez Gene 3240
Alt Symbol BP, HP2ALPHA2, HPA1S
Species Human
Gene Type protein-coding
Description haptoglobin
Other Description binding peptide|haptoglobin alpha(1S)-beta|haptoglobin alpha(2FS)-beta|haptoglobin, alpha polypeptide|haptoglobin, beta polypeptide|zonulin
Swissprots Q2PP15 Q6LBY9 Q9UC67 P00737 Q0VAC4 P00738 Q0VAC5 B0AZL5 Q3B7J0
Accessions AAA88078 AAA88080 AAC27432 ABC40729 CAA25248 CAA25926 EAW59194 EAW59195 EAW59196 EAW59197 P00738 AK055872 BAG51589 AK314700 BAF98793 BC017862 AAH17862 BC058031 AAH58031 BC070299 AAH70299 BC107587 AAI07588 BC121124 AAI21125 BC121125 AAI21126 CB117006 CB134891 K00422 AAA52687 K01763 AAA52684 L29394 AAA52685 M13192 T71743 X00637 CAA25267 XM_005255922 XP_005255979 NM_001126102 NP_001119574 NM_005143 NP_005134
Function As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. {ECO:0000269|PubMed:21248165}.
Subcellular Location Secreted.
Tissue Specificity Expressed by the liver and secreted in plasma.

Haptoglobin (2F4) - sc-69783 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Haptoglobin (2F4): sc-69783. Western blot analysis of Haptoglobin phenotypes purified from human plasma including Hp1-1 (A), Hp2-1 (B) and Hp2-2 (C), and Haptoglobin in human plasma (D).

Haptoglobin (26E11) - sc-69782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Haptoglobin (26E11): sc-69782. Western blot analysis of Haptoglobin phenotypes purified from human plasma including Hp1-1 (A), Hp2-1 (B) and Hp2-2 (C), and Haptoglobin in human plasma (D).

Haptoglobin (N-14) - sc-68667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Haptoglobin (S-15) - sc-68668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Haptoglobin α (B-2) - sc-365396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Haptoglobin α (B-2): sc-365396. Western blot analysis of Haptoglobin α expression in Hep G2 whole cell lysate.

Haptoglobin α (C-8) - sc-376893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Haptoglobin α (C-8): sc-376893. Western blot analysis of Haptoglobin α expression in HeLa (A) and Hep G2 (B) whole cell lysates.

Haptoglobin α (E-9) - sc-374208 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Haptoglobin α (E-9): sc-374208. Western blot analysis of Haptoglobin α expression in Hep G2 whole cell lysate.

Haptoglobin α (H-130) - sc-134464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Haptoglobin α (H-130): sc-134464. Western blot analysis of Haptoglobin α expression in human PBL whole cell lysate.

Haptoglobin α (M-80) - sc-134466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Haptoglobin α (M-80): sc-134466. Immunofluores-cence staining of methanol-fixed HeLa cells showing membrane localization.

Haptoglobin β (F-8) - sc-390962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Haptoglobin β (F-8): sc-390962. Western blot analysis of Haptoglobin β expression in Hep G2 whole cell lysate.

Anti-Haptoglobin antibody - ab117316 from Abcam

Host Chicken
Clonality Polyclonal
ab117316 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab117316 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- chicken IgY (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Haptoglobin antibody - ab85846 from Abcam

Prices $379.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Standard Curve for Haptoglobin (Analyte: Haptoglobin protein (ab77872)); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse polyclonal to Haptoglobin (ab52652) at 5µg/ml and Detector Antibody Rabbit polyclonal to Haptoglobin (ab85846) at 0.5µg/ml.

Anti-Haptoglobin antibody - ab97976 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, using ab97976 at 1/200 dilution. Lower image is merged with DNA probe.

Anti-Haptoglobin antibody - ab97969 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Haptoglobin antibody (ab97969) at 1/500 dilution + HeLa whole cell lysate at 30 µg

Anti-Haptoglobin antibody - ab75455 from Abcam

Host Chicken
Clonality Polyclonal
Anti-Haptoglobin antibody (ab75455) at 1/10000 dilution + Human serum at 2 µlSecondaryGoat-anti-IgY/Fc-HRP at 1/10000 dilution

Anti-Haptoglobin antibody - ab131146 from Abcam

Prices $376.00
Sizes 250 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human liver tissue labelling Haptoglobin with ab131146 at 2.5 µg/ml.

Anti-Haptoglobin antibody - ab34732 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal

Anti-Haptoglobin antibody - ab13431 from Abcam

Prices $368.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-Haptoglobin antibody - ab31205 from Abcam

Prices $368.00
Sizes 1 ml
Host Goat
Clonality Polyclonal

Anti-Haptoglobin antibody [1] - ab82517 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1
Anti-Haptoglobin antibody [1] (ab82517) at 1/1000 dilution + BGC823 whole cell lysate

Anti-Haptoglobin antibody [26E11] - ab133764 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 26E11
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human liver tissue labelling Haptoglobin with ab133764 at a 1/200 dilution followed by biotinylated horse anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen

Anti-Haptoglobin antibody [EPSISR7] - ab131236 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPSISR7
All lanes : Anti-Haptoglobin antibody [EPSISR7] (ab131236) at 1/10000 dilutionLane 1 : Human plasma lysateLane 2 : Human fetal liver lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Haptoglobin antibody [HG-36] - ab13429 from Abcam

Prices $400.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone HG-36
ab13429 staining Haptoglobin in human bronchoalveolar lavage cells by Immunocytochemistry/ Immunofluorescence.Cells were fixed in HOPE, blocked for 5 minutes at 25°C, then incubated with ab13429 at a 1/100 for 1 hour at 25°C. The secondary used was an Alexa-Fluor 488 conjugated goat anti-mouse polyclonal used at a 1/200 dilution. Counterstained with DAPI.See Abreview

Anti-Haptoglobulin beta antibody - ab124242 from Abcam

Prices $407.00
Sizes 50 µl
Host Goat
Clonality Polyclonal
ab124242 at 5 µg/ml, staining Haptoglobulin beta in Formalin-Fixed Human liver tissue by immunohistochemistry.

Anti-Haptoglobulin beta antibody [2B11] - ab118056 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B11
All lanes : Anti-Haptoglobulin beta antibody [2B11] (ab118056) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Haptoglobulin beta cDNALysates/proteins at 5 µg per lane.
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