| Gene Symbol |
HP
|
| Entrez Gene |
3240
|
| Alt Symbol |
BP, HP2ALPHA2, HPA1S
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
haptoglobin
|
| Other Description |
binding peptide|haptoglobin alpha(1S)-beta|haptoglobin alpha(2FS)-beta|haptoglobin, alpha polypeptide|haptoglobin, beta polypeptide|zonulin
|
| Swissprots |
Q2PP15 Q6LBY9 Q9UC67 P00737 Q0VAC4 P00738 Q0VAC5 B0AZL5 Q3B7J0
|
| Accessions |
AAA88078 AAA88080 AAC27432 ABC40729 CAA25248 CAA25926 EAW59194 EAW59195 EAW59196 EAW59197 P00738 AK055872 BAG51589 AK314700 BAF98793 BC017862 AAH17862 BC058031 AAH58031 BC070299 AAH70299 BC107587 AAI07588 BC121124 AAI21125 BC121125 AAI21126 CB117006 CB134891 K00422 AAA52687 K01763 AAA52684 L29394 AAA52685 M13192 T71743 X00637 CAA25267 XM_005255922 XP_005255979 NM_001126102 NP_001119574 NM_005143 NP_005134
|
| Function |
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. {ECO:0000269|PubMed:21248165}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed by the liver and secreted in plasma.
|
![Western Blot: Haptoglobin Overexpression Lysate (Adult Normal) [NBL1-11686] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Haptoglobin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1267_Haptoglobin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11686-img0002.jpg)