SH2B2

Gene Symbol SH2B2
Entrez Gene 10603
Alt Symbol APS
Species Human
Gene Type protein-coding
Description SH2B adaptor protein 2
Other Description SH2 and PH domain-containing adapter protein APS|SH2B adapter protein 2|adapter protein with pleckstrin homology and Src homology 2 domains
Swissprots A6ND74 O14492
Accessions EAW50232 EAW50233 O14492 AB000520 BAA22514 BF309652 BF434397 BI261466 CB053166 DN995670 XM_005276975 XP_005277032 XM_005276976 XP_005277033 XM_005276977 XP_005277034 XM_005276979 XP_005277036 XM_011515740 XP_011514042 XM_011515741 XP_011514043 NM_020979 NP_066189
Function Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
Tissue Specificity Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. {ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}.
Top Pathways Insulin signaling pathway, Neurotrophin signaling pathway

APS Antibody - 4832 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using APS Antibody.

APS (C-20) - sc-7223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APS (C-20): sc-7223. Western blot analysis of APS expression in BJAB whole cell lysate.

APS (H-120) - sc-25551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

APS (V-19) - sc-8894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APS (V-19): sc-8894. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic and membrane staining of glandular cells.

Anti-SH2B2 / APS Antibody (N-Terminus) - LS-C35051 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B2 / APS Antibody (aa620-632) - LS-C126877 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SH2B2 Antibody - NBP2-13305 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SH2B2 Antibody [NBP2-13305] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Human cell line RT-4Lane 3: Human cell line U-251MG sp

SH2B2 Antibody - NBP1-32149 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: SH2B2 Antibody [NBP1-32149] - SH2B2 Antibody [NBP1-32149- (30 ug of whole cell lysate) A:293T 7.5% SDS PAGE diluted at 1:1000.

Anti-SH2B2 antibody produced in rabbit - SAB2700281 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SH2B2: <B>Cat. No. SAB2700281</B>: Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using APS antibody at 1:100 dilution.

Anti-SH2B2 antibody produced in rabbit - HPA051131 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SH2B2:<B>Cat. No. HPA051131</B>: Immunohistochemical staining of human prostate shows moderate cytoplasmic and membranous positivity in glandular cells.

Anti-APS (center) antibody produced in rabbit - SAB1300902 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-APS (Center) Antibody: <B>Cat. No. SAB1300902</B>: APS in HL60 cell line lysates with Anti-APS (Center) Antibody at 4.0 μg/mL.

SH2B2 Antibody (OAAF04282) - OAAF04282 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SH2B2 Antibody - abx014882 from Abbexa

Host Rabbit
Clonality Polyclonal

Goat Anti-Human SH2B2 - DS-PB-00185 from RayBiotech

Host Goat

Anti-APS antibody - STJ91650 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

SH2B2 antibody - 19746-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

SH2B2 Antibody - 37426 from Signalway Antibody

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #37426 at dilution 1/30.

SH2B2 Antibody - E11-18704C from Enogene

Prices $225.00
Sizes 100 μg
Host Rabbit

APS Polyclonal Antibody - PA5-17608 from Thermo Fisher Scientific

Prices $275.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of APS in paraffin-embedded human lung carcinoma using an APS polyclonal antibody (Product # PA5-17608).

SH2B2, Polyclonal Antibody - MBS2522503 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

SH2B2, Polyclonal Antibody - MBS2527947 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

AFFN-SH2B2-4A7 - AFFN-SH2B2-4A7 from Developmental Studies Hybridoma Bank

Host Mouse
Clonality Monoclonal

SH2B2 Antibody - CSB-PA966248 from Cusabio

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/30.

SH2B2 Antibody - CSB-PA250790 from Cusabio

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/30.

SH2B2 Antibody - A03S0082 from BlueGene Biotech
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