Gene Symbol | SH2B2 |
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Entrez Gene | 10603 |
Alt Symbol | APS |
Species | Human |
Gene Type | protein-coding |
Description | SH2B adaptor protein 2 |
Other Description | SH2 and PH domain-containing adapter protein APS|SH2B adapter protein 2|adapter protein with pleckstrin homology and Src homology 2 domains |
Swissprots | A6ND74 O14492 |
Accessions | EAW50232 EAW50233 O14492 AB000520 BAA22514 BF309652 BF434397 BI261466 CB053166 DN995670 XM_005276975 XP_005277032 XM_005276976 XP_005277033 XM_005276977 XP_005277034 XM_005276979 XP_005277036 XM_011515740 XP_011514042 XM_011515741 XP_011514043 NM_020979 NP_066189 |
Function | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region. |
Tissue Specificity | Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. {ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}. |
Top Pathways | Insulin signaling pathway, Neurotrophin signaling pathway |
APS CRISPR/Cas9 KO Plasmid (h) - sc-409223 from Santa Cruz Biotechnology
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APS HDR Plasmid (h) - sc-409223-HDR from Santa Cruz Biotechnology
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APS Double Nickase Plasmid (h) - sc-409223-NIC from Santa Cruz Biotechnology
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APS Double Nickase Plasmid (h2) - sc-409223-NIC-2 from Santa Cruz Biotechnology
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APS CRISPR Activation Plasmid (h) - sc-409223-ACT from Santa Cruz Biotechnology
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APS CRISPR Activation Plasmid (h2) - sc-409223-ACT-2 from Santa Cruz Biotechnology
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APS Lentiviral Activation Particles (h) - sc-409223-LAC from Santa Cruz Biotechnology
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APS Lentiviral Activation Particles (h2) - sc-409223-LAC-2 from Santa Cruz Biotechnology
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APS siRNA (h) - sc-29710 from Santa Cruz Biotechnology
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APS shRNA Plasmid (h) - sc-29710-SH from Santa Cruz Biotechnology
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APS shRNA (h) Lentiviral Particles - sc-29710-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN19245 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19245 from Sigma-Aldrich
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SH2B2 siRNA (Human) - CRH7217 from Cohesion Biosciences
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SH2B2 - MBS827688 from MyBioSource
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shRNA set against Human Sh2b2 (NM_020979.3) - SHH406468 from Creative biogene
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SH2B2 shRNA Plasmid (Human) - CHH7217 from Cohesion Biosciences
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SH2B2 miRNA 3'UTR clone - MiUTR3H-07550 from Creative biogene
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