SH2B2

Gene Symbol SH2B2
Entrez Gene 10603
Alt Symbol APS
Species Human
Gene Type protein-coding
Description SH2B adaptor protein 2
Other Description SH2 and PH domain-containing adapter protein APS|SH2B adapter protein 2|adapter protein with pleckstrin homology and Src homology 2 domains
Swissprots A6ND74 O14492
Accessions EAW50232 EAW50233 O14492 AB000520 BAA22514 BF309652 BF434397 BI261466 CB053166 DN995670 XM_005276975 XP_005277032 XM_005276976 XP_005277033 XM_005276977 XP_005277034 XM_005276979 XP_005277036 XM_011515740 XP_011514042 XM_011515741 XP_011514043 NM_020979 NP_066189
Function Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
Tissue Specificity Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. {ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}.
Top Pathways Insulin signaling pathway, Neurotrophin signaling pathway

APS CRISPR/Cas9 KO Plasmid (h) - sc-409223 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS HDR Plasmid (h) - sc-409223-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS Double Nickase Plasmid (h) - sc-409223-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS Double Nickase Plasmid (h2) - sc-409223-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS CRISPR Activation Plasmid (h) - sc-409223-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS CRISPR Activation Plasmid (h2) - sc-409223-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS Lentiviral Activation Particles (h) - sc-409223-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS Lentiviral Activation Particles (h2) - sc-409223-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APS siRNA (h) - sc-29710 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APS shRNA Plasmid (h) - sc-29710-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APS shRNA (h) Lentiviral Particles - sc-29710-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19245 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19245 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SH2B2 siRNA (Human) - CRH7217 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SH2B2 - MBS827688 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Sh2b2 (NM_020979.3) - SHH406468 from Creative biogene

Category siRNA
Species Reactivities Human

SH2B2 shRNA Plasmid (Human) - CHH7217 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SH2B2 miRNA 3'UTR clone - MiUTR3H-07550 from Creative biogene

Species Reactivities Human
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