| Gene Symbol |
SH2B2
|
| Entrez Gene |
10603
|
| Alt Symbol |
APS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH2B adaptor protein 2
|
| Other Description |
SH2 and PH domain-containing adapter protein APS|SH2B adapter protein 2|adapter protein with pleckstrin homology and Src homology 2 domains
|
| Swissprots |
A6ND74 O14492
|
| Accessions |
EAW50232 EAW50233 O14492 AB000520 BAA22514 BF309652 BF434397 BI261466 CB053166 DN995670 XM_005276975 XP_005277032 XM_005276976 XP_005277033 XM_005276977 XP_005277034 XM_005276979 XP_005277036 XM_011515740 XP_011514042 XM_011515741 XP_011514043 NM_020979 NP_066189
|
| Function |
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
|
| Tissue Specificity |
Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. {ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}.
|
| Top Pathways |
Insulin signaling pathway, Neurotrophin signaling pathway
|