SH2B2

Gene Symbol	SH2B2
Entrez Gene	10603
Alt Symbol	APS
Species	Human
Gene Type	protein-coding
Description	SH2B adaptor protein 2
Other Description	SH2 and PH domain-containing adapter protein APS|SH2B adapter protein 2|adapter protein with pleckstrin homology and Src homology 2 domains
Swissprots	A6ND74 O14492
Accessions	EAW50232 EAW50233 O14492 AB000520 BAA22514 BF309652 BF434397 BI261466 CB053166 DN995670 XM_005276975 XP_005277032 XM_005276976 XP_005277033 XM_005276977 XP_005277034 XM_005276979 XP_005277036 XM_011515740 XP_011514042 XM_011515741 XP_011514043 NM_020979 NP_066189
Function	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
Tissue Specificity	Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. {ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}.
Top Pathways	Insulin signaling pathway, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human SH2B2 Protein - H00010603-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SH2B2 Peptide - P2797 from Novus Biologicals Category Peptide Species Human

APS-Antibody-Y629-Blocking-Peptide - BP7747a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SH2B2 / APS - H00010603-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SH2B2 / APS - H00010603-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human SH2B adapter protein 2(SH2B2) - CSB-YP021207HU CSB-EP021207HU CSB-BP021207HU CSB-MP021207HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SH2B2 / APS - TP329333 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SH2B2 Protein - NBP2-13305PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

APS-Antibody-Center-Blocking-Peptide - BP7747c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-APSY629-Antibody-Blocking-peptide - BP3703a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

SH2B2 Peptide, Human - M34GP14154H from Creative Peptides Category Peptide Source Synthetic. Species Human

SH2B adapter protein 2 (SH2B2), Recombinant Protein - MBS1144491 from MyBioSource Category Protein Prices $1,430.00, $1,430.00, $1,655.00, $1,655.00, $2,420.00, $2,420.00, $2,860.00, $2,860.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human APS protein, GST-tagged - APS-730H from Creative Biomart Category Protein Source Wheat Germ Species Human

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