EYA4

Gene Symbol EYA4
Entrez Gene 2070
Alt Symbol CMD1J, DFNA10
Species Human
Gene Type protein-coding
Description EYA transcriptional coactivator and phosphatase 4
Other Description dJ78N10.1 (eyes absent)|eyes absent homolog 4
Swissprots B7Z7F7 O95677 O95464 O95679 Q8IW39 Q9NTR7
Accessions CAA76891 EAW48004 EAW48005 EAW48006 O95677 AJ007993 CAA07816 AJ007994 CAA07817 AK295798 BAG58618 AK299378 BAG61368 AK301950 BAH13593 AW613879 BC014193 AAH14193 BC030588 BC041063 AAH41063 BX490250 DA760903 EU446856 ABZ92385 Y17114 CAA76636 XM_005266851 XP_005266908 XM_005266852 XP_005266909 XM_005266853 XP_005266910 XM_011535540 XP_011533842 XM_011535541 XP_011533843 XM_011535542 XP_011533844 NM_001301012 NP_001287941 NM_001301013 NP_001287942 NM_004100 NP_004091 NM_172103 NP_742101 NM_172105 NP_742103 NM_172104
Function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Highly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:15735644}.

EYA4 (E-11) - sc-393111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EYA4 (E-11): sc-393111. Western blot analysis of EYA4 expression in HeLa (A) and A2058 (B) whole cell lysates.

EYA4 (E-20) - sc-15107 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EYA4 (H-124) - sc-366856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EYA4 (H-124): sc-366856. Western blot analysis of EYA4 expression in HeLa (A) and A2058 (B) whole cell lysates.

EYA4 (T-21) - sc-15106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EYA4 (T-21): sc-15106. Western blot analysis of EYA4 expression in HeLa (A) and A2058 (B) whole cell lysates.

Anti-EYA4 antibody - ab110148 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human liver by Immunohistochemistry.

Anti-EYA4 antibody - ab102648 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EYA4 antibody (ab102648) at 1/100 dilution + A2058 cell lysate at 35 µg

Anti-EYA4 antibody - ab93865 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EYA4 antibody (ab93865) at 0.4 µg/mlLane 1 : HeLa cell lysate at 50 µgLane 2 : HeLa cell lysate at 15 µgLane 3 : HeLa cell lysate at 5 µgdeveloped using the ECL technique

Anti-EYA4 antibody - Aminoterminal end - ab47990 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-30) - LS-C167872 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human skeletal muscle reacted with EYA4 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-EYA4 Antibody (aa100-150) - LS-C286124 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EYA4 by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-EYA4 used at a dilution of 1:200 (1 Detection: DAB.

Anti-EYA4 Antibody (aa100-150) - LS-C285975 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EYA4 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-EYA4 used at a dilution of 1:250.

Anti-EYA4 Antibody (aa2-16) IHC-plus™ - LS-B4327 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-EYA4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4327 concentration 3.75 ug/ml.

Anti-EYA4 Antibody (aa1-30, AP) - LS-C235102 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-30, APC) - LS-C235103 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-30, Biotin) - LS-C235104 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-30, FITC) - LS-C235105 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (N-Terminus) - LS-C146384 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EYA4 antibody LS-C146384 Western blot of Mouse Thymus lysate. Antibody concentration 1 ug/ml.

Anti-EYA4 Antibody (aa1-30, Azide-free, HRP) - LS-C249944 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-50) - LS-C289358 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-30) - LS-C321235 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (aa1-30, PE) - LS-C235109 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA4 Antibody (N-Terminus) - LS-C345336 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of EYA4 Antibody with human HeLa Whole Cell lysate.

EYA4 Antibody - NBP1-41100 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EYA4 Antibody [NBP1-41100] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-EYA4 antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. EYA4 was also immunoprecipitated by rabbit anti-EYA4 antibody NBP1-41099, which recognizes an upstream epitope.

EYA4 Antibody - NBP1-85548 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EYA4 Antibody - NBP1-85547 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EYA4 Antibody [NBP1-85547] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp
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