| Gene Symbol |
EYA4
|
| Entrez Gene |
2070
|
| Alt Symbol |
CMD1J, DFNA10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EYA transcriptional coactivator and phosphatase 4
|
| Other Description |
dJ78N10.1 (eyes absent)|eyes absent homolog 4
|
| Swissprots |
B7Z7F7 O95677 O95464 O95679 Q8IW39 Q9NTR7
|
| Accessions |
CAA76891 EAW48004 EAW48005 EAW48006 O95677 AJ007993 CAA07816 AJ007994 CAA07817 AK295798 BAG58618 AK299378 BAG61368 AK301950 BAH13593 AW613879 BC014193 AAH14193 BC030588 BC041063 AAH41063 BX490250 DA760903 EU446856 ABZ92385 Y17114 CAA76636 XM_005266851 XP_005266908 XM_005266852 XP_005266909 XM_005266853 XP_005266910 XM_011535540 XP_011533842 XM_011535541 XP_011533843 XM_011535542 XP_011533844 NM_001301012 NP_001287941 NM_001301013 NP_001287942 NM_004100 NP_004091 NM_172103 NP_742101 NM_172105 NP_742103 NM_172104
|
| Function |
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:15735644}.
|