EYA4
| Gene Symbol | EYA4 |
|---|---|
| Entrez Gene | 2070 |
| Alt Symbol | CMD1J, DFNA10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EYA transcriptional coactivator and phosphatase 4 |
| Other Description | dJ78N10.1 (eyes absent)|eyes absent homolog 4 |
| Swissprots | B7Z7F7 O95677 O95464 O95679 Q8IW39 Q9NTR7 |
| Accessions | CAA76891 EAW48004 EAW48005 EAW48006 O95677 AJ007993 CAA07816 AJ007994 CAA07817 AK295798 BAG58618 AK299378 BAG61368 AK301950 BAH13593 AW613879 BC014193 AAH14193 BC030588 BC041063 AAH41063 BX490250 DA760903 EU446856 ABZ92385 Y17114 CAA76636 XM_005266851 XP_005266908 XM_005266852 XP_005266909 XM_005266853 XP_005266910 XM_011535540 XP_011533842 XM_011535541 XP_011533843 XM_011535542 XP_011533844 NM_001301012 NP_001287941 NM_001301013 NP_001287942 NM_004100 NP_004091 NM_172103 NP_742101 NM_172105 NP_742103 NM_172104 |
| Function | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Highly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:15735644}. |
EYA4 CRISPR/Cas9 KO Plasmid (h) - sc-404355 from Santa Cruz Biotechnology
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EYA4 HDR Plasmid (h) - sc-404355-HDR from Santa Cruz Biotechnology
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EYA4 Double Nickase Plasmid (h) - sc-404355-NIC from Santa Cruz Biotechnology
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EYA4 Double Nickase Plasmid (h2) - sc-404355-NIC-2 from Santa Cruz Biotechnology
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EYA4 CRISPR Activation Plasmid (h) - sc-404355-ACT from Santa Cruz Biotechnology
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EYA4 CRISPR Activation Plasmid (h2) - sc-404355-ACT-2 from Santa Cruz Biotechnology
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EYA4 Lentiviral Activation Particles (h) - sc-404355-LAC from Santa Cruz Biotechnology
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EYA4 Lentiviral Activation Particles (h2) - sc-404355-LAC-2 from Santa Cruz Biotechnology
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EYA4 siRNA (h) - sc-41952 from Santa Cruz Biotechnology
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EYA4 shRNA Plasmid (h) - sc-41952-SH from Santa Cruz Biotechnology
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EYA4 shRNA (h) Lentiviral Particles - sc-41952-V from Santa Cruz Biotechnology
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EYA4 RNAi - H00002070-R08 from Novus Biologicals
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EYA4 RNAi - H00002070-R05 from Novus Biologicals
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EYA4 RNAi - H00002070-R06 from Novus Biologicals
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MISSION® esiRNA - EHU080581 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0219 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0218 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0217 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8064 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8064 from Sigma-Aldrich
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EYA4 siRNA (Human) - CRH1445 from Cohesion Biosciences
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EYA4 RNAi - H00002070-R07 from Novus Biologicals
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EYA4 - MBS8221154 from MyBioSource
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shRNA set against Human EYA4 (NM_004100.4) - SHH288305 from Creative biogene
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Human EYA4 siRNA - orb261947 from Biorbyt
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