PAN3

Gene Symbol	PAN3
Entrez Gene	255967
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	PAN3 poly(A) specific ribonuclease subunit
Other Description	PAB-dependent poly(A)-specific ribonuclease subunit 3|PAB-dependent poly(A)-specific ribonuclease subunit PAN3|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 3|PABP1-dependent poly A-specific ribonuclease subunit PAN3|PAN deadenylation complex subunit 3|PAN3 poly(A) specific ribonuclease subunit homolog
Swissprots	Q5HYG6 Q76E13 Q5T516 B7Z3W7 A1A4Y9 A1A4Y8 Q5T515 Q8NBA6 B1ALF1 Q0D2P2 A0N0X1 Q5TBA0 Q58A45
Accessions	ABK41888 EAX08430 Q58A45 AB107584 BAD02262 AB109552 BAD93184 AK091307 BAC03632 AK131556 BAD18690 AK296435 BAH12353 AY358261 AAQ88628 BC024318 AAH24318 BC128179 AAI28180 BC128180 AAI28181 BE671612 BX647740 CAI45987 XM_005266332 XP_005266389 XM_005266333 XP_005266390 XM_005266334 XP_005266391 XM_006719802 XP_006719865 XM_011535032 XP_011533334 XM_011535033 XP_011533335 XM_011535034 XP_011533336 XM_011535035 XP_011533337 XR_941549 XR_941550 XR_941551 XR_941552 NM_175854 NP_787050
Function	Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.
Subcellular Location	Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Pan3 (A-9) - sc-376434 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Pan3 (D-19) - sc-84548 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Pan3 (K-20) - sc-84550 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-Pan3 antibody - ab189413 from Abcam Prices $407.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Pan3 antibody - ab88642 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Pan3 antibody - ab104107 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Pan3 antibody - ab96325 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755, APC) - LS-C238646 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755, Biotin) - LS-C238647 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755, AP) - LS-C238650 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755, FITC) - LS-C238648 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799, AP) - LS-C238652 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799, Biotin) - LS-C238653 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755, PE) - LS-C238651 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799, FITC) - LS-C238654 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799, APC) - LS-C238655 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799, PE) - LS-C238659 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799, Azide-free, HRP) - LS-C248396 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755, Azide-free, HRP) - LS-C248395 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa780-810) - LS-C323770 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa580-609) - LS-C323771 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa727-755) - LS-C164519 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody (aa771-799) - LS-C163353 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PAN3 Antibody IHC-plus™ - LS-B8925 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

PAN3 Antibody - NBP1-89438 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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