PAN3

Gene Symbol	PAN3
Entrez Gene	255967
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	PAN3 poly(A) specific ribonuclease subunit
Other Description	PAB-dependent poly(A)-specific ribonuclease subunit 3|PAB-dependent poly(A)-specific ribonuclease subunit PAN3|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 3|PABP1-dependent poly A-specific ribonuclease subunit PAN3|PAN deadenylation complex subunit 3|PAN3 poly(A) specific ribonuclease subunit homolog
Swissprots	Q5HYG6 Q76E13 Q5T516 B7Z3W7 A1A4Y9 A1A4Y8 Q5T515 Q8NBA6 B1ALF1 Q0D2P2 A0N0X1 Q5TBA0 Q58A45
Accessions	ABK41888 EAX08430 Q58A45 AB107584 BAD02262 AB109552 BAD93184 AK091307 BAC03632 AK131556 BAD18690 AK296435 BAH12353 AY358261 AAQ88628 BC024318 AAH24318 BC128179 AAI28180 BC128180 AAI28181 BE671612 BX647740 CAI45987 XM_005266332 XP_005266389 XM_005266333 XP_005266390 XM_005266334 XP_005266391 XM_006719802 XP_006719865 XM_011535032 XP_011533334 XM_011535033 XP_011533335 XM_011535034 XP_011533336 XM_011535035 XP_011533337 XR_941549 XR_941550 XR_941551 XR_941552 NM_175854 NP_787050
Function	Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.
Subcellular Location	Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Pan3 peptide - ab102602 from Abcam Category Peptide

Human Pan3 protein fragment - ab166056 from Abcam Category Protein Source Wheat germ Species Human

PAN3 Antibody Blocking Peptide - LS-E2822 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAN3 Antibody Blocking Peptide - LS-E7665 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PAN3 Protein - H00255967-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PAN3-Antibody-C-term-Blocking-Peptide - BP4958b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NALP6 Peptide - GTX85157-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

PAN3 - H00255967-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAN3 - H00255967-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human PAN3 - PAN3-1708H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit 3(PAN3) ,partial - CSB-YP701504HU CSB-EP701504HU CSB-BP701504HU CSB-MP701504HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PAN3 - TP318027 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PAB-dependent poly (A)-specific ribonuclease subunit 3 (PAN3), partial, Recombinant Protein - MBS1390375 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PAN3 Recombinant Protein Antigen - NBP1-89438PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PAN3 Peptide, Human - M34GP11275H from Creative Peptides Category Peptide Source Synthetic. Species Human

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