PAN3

Gene Symbol PAN3
Entrez Gene 255967
Alt Symbol -
Species Human
Gene Type protein-coding
Description PAN3 poly(A) specific ribonuclease subunit
Other Description PAB-dependent poly(A)-specific ribonuclease subunit 3|PAB-dependent poly(A)-specific ribonuclease subunit PAN3|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 3|PABP1-dependent poly A-specific ribonuclease subunit PAN3|PAN deadenylation complex subunit 3|PAN3 poly(A) specific ribonuclease subunit homolog
Swissprots Q5HYG6 Q76E13 Q5T516 B7Z3W7 A1A4Y9 A1A4Y8 Q5T515 Q8NBA6 B1ALF1 Q0D2P2 A0N0X1 Q5TBA0 Q58A45
Accessions ABK41888 EAX08430 Q58A45 AB107584 BAD02262 AB109552 BAD93184 AK091307 BAC03632 AK131556 BAD18690 AK296435 BAH12353 AY358261 AAQ88628 BC024318 AAH24318 BC128179 AAI28180 BC128180 AAI28181 BE671612 BX647740 CAI45987 XM_005266332 XP_005266389 XM_005266333 XP_005266390 XM_005266334 XP_005266391 XM_006719802 XP_006719865 XM_011535032 XP_011533334 XM_011535033 XP_011533335 XM_011535034 XP_011533336 XM_011535035 XP_011533337 XR_941549 XR_941550 XR_941551 XR_941552 NM_175854 NP_787050
Function Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.
Subcellular Location Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}.
Top Pathways RNA degradation

Human-PAN3-cDNA-Clone - DC14535 from Abgent, a WuXi AppTec company

Prices $927.45
Sizes 10 µg
Species Human
Accession BC128180

PAN3 - MBS1268973 from MyBioSource

Species Human
Accession BC128180

Mouse PAN3 ORF clone (NM_175854.7) - CDCL145757 from Creative biogene

Species Human

Human PAN3 ORF Clone (BC128180) - CDCS417518 from Creative biogene

Species Human
Accession Q58A45
Search more