| Gene Symbol |
PAN3
|
| Entrez Gene |
255967
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PAN3 poly(A) specific ribonuclease subunit
|
| Other Description |
PAB-dependent poly(A)-specific ribonuclease subunit 3|PAB-dependent poly(A)-specific ribonuclease subunit PAN3|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 3|PABP1-dependent poly A-specific ribonuclease subunit PAN3|PAN deadenylation complex subunit 3|PAN3 poly(A) specific ribonuclease subunit homolog
|
| Swissprots |
Q5HYG6 Q76E13 Q5T516 B7Z3W7 A1A4Y9 A1A4Y8 Q5T515 Q8NBA6 B1ALF1 Q0D2P2 A0N0X1 Q5TBA0 Q58A45
|
| Accessions |
ABK41888 EAX08430 Q58A45 AB107584 BAD02262 AB109552 BAD93184 AK091307 BAC03632 AK131556 BAD18690 AK296435 BAH12353 AY358261 AAQ88628 BC024318 AAH24318 BC128179 AAI28180 BC128180 AAI28181 BE671612 BX647740 CAI45987 XM_005266332 XP_005266389 XM_005266333 XP_005266390 XM_005266334 XP_005266391 XM_006719802 XP_006719865 XM_011535032 XP_011533334 XM_011535033 XP_011533335 XM_011535034 XP_011533336 XM_011535035 XP_011533337 XR_941549 XR_941550 XR_941551 XR_941552 NM_175854 NP_787050
|
| Function |
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}.
|
| Top Pathways |
RNA degradation
|