PAN3
| Gene Symbol | PAN3 |
|---|---|
| Entrez Gene | 255967 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | PAN3 poly(A) specific ribonuclease subunit |
| Other Description | PAB-dependent poly(A)-specific ribonuclease subunit 3|PAB-dependent poly(A)-specific ribonuclease subunit PAN3|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 3|PABP1-dependent poly A-specific ribonuclease subunit PAN3|PAN deadenylation complex subunit 3|PAN3 poly(A) specific ribonuclease subunit homolog |
| Swissprots | Q5HYG6 Q76E13 Q5T516 B7Z3W7 A1A4Y9 A1A4Y8 Q5T515 Q8NBA6 B1ALF1 Q0D2P2 A0N0X1 Q5TBA0 Q58A45 |
| Accessions | ABK41888 EAX08430 Q58A45 AB107584 BAD02262 AB109552 BAD93184 AK091307 BAC03632 AK131556 BAD18690 AK296435 BAH12353 AY358261 AAQ88628 BC024318 AAH24318 BC128179 AAI28180 BC128180 AAI28181 BE671612 BX647740 CAI45987 XM_005266332 XP_005266389 XM_005266333 XP_005266390 XM_005266334 XP_005266391 XM_006719802 XP_006719865 XM_011535032 XP_011533334 XM_011535033 XP_011533335 XM_011535034 XP_011533336 XM_011535035 XP_011533337 XR_941549 XR_941550 XR_941551 XR_941552 NM_175854 NP_787050 |
| Function | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}. |
| Subcellular Location | Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}. |
| Top Pathways | RNA degradation |
Pan3 CRISPR/Cas9 KO Plasmid (h) - sc-405926 from Santa Cruz Biotechnology
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Pan3 HDR Plasmid (h) - sc-405926-HDR from Santa Cruz Biotechnology
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Pan3 Double Nickase Plasmid (h) - sc-405926-NIC from Santa Cruz Biotechnology
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Pan3 Double Nickase Plasmid (h2) - sc-405926-NIC-2 from Santa Cruz Biotechnology
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Pan3 CRISPR Activation Plasmid (h) - sc-405926-ACT from Santa Cruz Biotechnology
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Pan3 CRISPR Activation Plasmid (h2) - sc-405926-ACT-2 from Santa Cruz Biotechnology
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Pan3 Lentiviral Activation Particles (h) - sc-405926-LAC from Santa Cruz Biotechnology
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Pan3 Lentiviral Activation Particles (h2) - sc-405926-LAC-2 from Santa Cruz Biotechnology
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Pan3 siRNA (h) - sc-76039 from Santa Cruz Biotechnology
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Pan3 shRNA Plasmid (h) - sc-76039-SH from Santa Cruz Biotechnology
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Pan3 shRNA (h) Lentiviral Particles - sc-76039-V from Santa Cruz Biotechnology
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PAN3 RNAi - H00255967-R02 from Novus Biologicals
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MISSION® esiRNA - EHU044821 from Sigma-Aldrich
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MISSION® siRNA - SIHK1506 from Sigma-Aldrich
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MISSION® siRNA - SIHK1505 from Sigma-Aldrich
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MISSION® siRNA - SIHK1507 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16302 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16302 from Sigma-Aldrich
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PAN3 siRNA (Human) - CRJ6738 from Cohesion Biosciences
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shRNA set against Human Pan3 (NM_175854.7) - SHH370332 from Creative biogene
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Human PAN3 siRNA - orb277239 from Biorbyt
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PAN3 shRNA Plasmid (Human) - CHJ6738 from Cohesion Biosciences
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