CXCR1

Gene Symbol CXCR1
Entrez Gene 3577
Alt Symbol C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Species Human
Gene Type protein-coding
Description chemokine (C-X-C motif) receptor 1
Other Description C-X-C chemokine receptor type 1|CXC-R1|CXCR-1|IL-8 receptor type 1|IL-8R A|high affinity interleukin-8 receptor A|interleukin 8 receptor, alpha|interleukin-8 receptor type 1|interleukin-8 receptor type A
Swissprots Q2YEF8 B2R6Q3 P25024 Q2YEG7 Q8N6T6 Q9P2T9 Q9P2U2 Q2YEG4 Q9P2T8 Q2YEG8 Q9P2U1 Q2YEG5 Q6IN95 Q53R18 Q9P2U0
Accessions AAA59160 AAA64378 AAT46689 AAX93212 AAY21512 AAY21513 AAY21514 AAY21515 AAY21516 AAY21519 AAY21522 AAY21523 BAA92290 BAA92291 BAA92292 BAA92293 BAA92294 CAA46688 EAW70590 P25024 AK298647 BAG60821 AK309632 AK312668 BAG35550 BC028221 AAH28221 BC072397 AAH72397 CA425329 CR541994 CAG46791 CR542029 CAG46826 DQ891718 ABM82644 DQ894895 ABM85821 L19591 AAB59436 M68932 AAA59159 U11871 AAA64379 NM_000634 NP_000625
Function Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Top Pathways Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, Endocytosis, Chemokine signaling pathway

IL-8RA (C-20) - sc-988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-8RA (C-20): sc-988. Western blot analysis of IL-8RA expression in 293T whole cell lysate.

IL-8RA (N-19) - sc-989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-8RA (N-19): sc-989. Western blot analysis of IL-8RA expression in human PBL whole cell lysate.

IL-8RA (B-1) - sc-7303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-8RA (B-1) PE: sc-7303 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

IL-8RA/B (H-100) - sc-30008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-8RA/B (H-100): sc-30008. Western blot analysis of IL-8RA expression in non-transfected: sc-117752 (A) and human IL-8RA transfected: sc-117444 (B) 293T whole cell lysates.

Anti-CXCR1 antibody - ab14936 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab14936 staining CXCR1 in rat whole hippocampus tissue by Immunohistochemistry (Frozen sections). After fixation in 4% PFA in PBS (pH 7.4), brains were cryoprotected in 30% sucrose in PBS at +4°C, frozen, and thereafter kept at -80°C until used. For the immunostaining, brains were cryosectioned in 30 µm slices, collected in PBS (pH 7.4), and processed in a free-floating system. Slices were first incubated in the blocking solution (BS) containing 2% bovine serum albumin, 2% goat serum, and 0.1% Triton X-100 in PBS (pH 7.4) for 1 hour at room temperature, and thereafter with the primary antibody for 24–48 hours at +4°C in BS at a 1/1000 dilution. After washing in PBS, slices were incubated with an Alexa 568 secondary antibody at a 1/2000 dilution.

Anti-CXCR1 antibody - ab124344 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CXCR1 antibody (ab124344) at 1/500 dilution + Human fetal skin lysate.

Anti-CXCR1 antibody - ab150548 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling CXCR1 with ab150548 at 20 µg/ml.

Anti-CXCR1 antibody - ab195985 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CXCR1 antibody (ab195985) at 0.3 µg/ml + Human Breast cancer lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CXCR1 antibody [42705.111] - ab10400 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 42705.111

Anti-CXCR1 antibody [501] - ab60254 from Abcam

Prices $381.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 501
Isolated human neutrophils were incubated with 0.25 µg ab60254 followed by staining with goat F (ab’)2 anti-mouse IgG FITC [shaded peak]. Specificity of signal was confirmed by staining the neutrophils with 0.25 µg mouse IgG1 isotype control followed by the secondary antibody [unshaded peak]. The data indicate that 100% of the isolated neutrophil population stains positive for this CXCR1 (M2 region).

Anti-CXCR1 antibody [MM0221-7D22] - ab89251 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0221-7D22

Anti-CXCR1 antibody - C-terminal - ab137351 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CXCR1 antibody - C-terminal (ab137351) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-CXCR1 Antibody - LS-C14716 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR1 Antibody (N-Terminus) - LS-C14719 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXCR1 Antibody - LS-C26947 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR1 Antibody (N-Terminus) - LS-C42728 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXCR1 Antibody (C-Terminus) - LS-C113012 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-CXCR1 Antibody (C-Terminus) IHC-plus™ - LS-A808 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CXCR1 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A808 dilution 16 ug/ml.

Anti-CXCR1 Antibody (FITC) - LS-C196110 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR1 Antibody - LS-C661 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of 15 ug of whole cell lysate from Raw cells with antibody at 2 ug/ml dilution.

Anti-CXCR1 Antibody - LS-C341081 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXCR1 Antibody (clone 8F1-1-4, FITC) - LS-C106110 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 8F1-1-4
Staining of normal human peripheral blood cells with PE anti-human CD182 (5E8-C7-F10) (LS-C106046) and FITC anti-human CD181 (8F1-1-4). Cells in the large scatter population were used for analysis.

Anti-CXCR1 Antibody (clone 8F1-1-4) - LS-C106874 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 8F1-1-4
Staining of normal human peripheral blood cells 0.25 ug of Purified anti-human CD181 (8F1-1-4) (right) followed by PE Donkey F(ab')2 Fragment Anti-Mouse IgG (H+L, Minimal Reactivity to Rat IgG). Cells in the large scatter population were used for analysis.

Anti-CXCR1 Antibody - LS-C26948 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Isolated human neutrophils were incubated with 0.25 g anti-human CXCR1 followed by staining with goat F(ab')2 anti-mouse IgG FITC [shaded peak]. Specificity of signal was confirmed by staining the neutrophils with 0.25 g mouse IgG1 isotype control followed by the secondary antibody [unshaded peak]. The data indicate that 100% of the isolated neutrophil population stains positive for this IL-8 receptor (M2 region).

Anti-CXCR1 Antibody (N-Terminus) - LS-C178869 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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