| Gene Symbol |
PHKA1
|
| Entrez Gene |
5255
|
| Alt Symbol |
PHKA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphorylase kinase, alpha 1 (muscle)
|
| Other Description |
phosphorylase b kinase regulatory subunit alpha skeletal muscle isoform|phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform|phosphorylase kinase alpha M subunit|phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis
|
| Swissprots |
Q2M3D7 P46020 B7ZL07 B7ZL05
|
| Accessions |
EAW71825 EAW71826 P46020 AK123357 AW450116 BC104944 AAI04945 BC143499 AAI43500 BC143501 AAI43502 BJ998054 BX647542 DA171597 DA998603 DR002787 X73874 CAA52083 X73878 XM_006724661 XP_006724724 NM_001122670 NP_001116142 NM_001172436 NP_001165907 NM_002637 NP_002628
|
| Function |
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
|
| Tissue Specificity |
Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested.
|
| Top Pathways |
Insulin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway
|
![Western Blot: PHKA1 Overexpression Lysate (Adult Normal) [NBP2-08089] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PHKA1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5868_PHKA1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08089-img0001.jpg)