Gene Symbol | PHKA1 |
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Entrez Gene | 5255 |
Alt Symbol | PHKA |
Species | Human |
Gene Type | protein-coding |
Description | phosphorylase kinase, alpha 1 (muscle) |
Other Description | phosphorylase b kinase regulatory subunit alpha skeletal muscle isoform|phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform|phosphorylase kinase alpha M subunit|phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis |
Swissprots | Q2M3D7 P46020 B7ZL07 B7ZL05 |
Accessions | EAW71825 EAW71826 P46020 AK123357 AW450116 BC104944 AAI04945 BC143499 AAI43500 BC143501 AAI43502 BJ998054 BX647542 DA171597 DA998603 DR002787 X73874 CAA52083 X73878 XM_006724661 XP_006724724 NM_001122670 NP_001116142 NM_001172436 NP_001165907 NM_002637 NP_002628 |
Function | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
Tissue Specificity | Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested. |
Top Pathways | Insulin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway |
PHKA1 CRISPR/Cas9 KO Plasmid (h) - sc-410935 from Santa Cruz Biotechnology
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PHKA1 HDR Plasmid (h) - sc-410935-HDR from Santa Cruz Biotechnology
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PHKA1 Double Nickase Plasmid (h) - sc-410935-NIC from Santa Cruz Biotechnology
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PHKA1 Double Nickase Plasmid (h2) - sc-410935-NIC-2 from Santa Cruz Biotechnology
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PHKA1 CRISPR Activation Plasmid (h) - sc-410935-ACT from Santa Cruz Biotechnology
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PHKA1 CRISPR Activation Plasmid (h2) - sc-410935-ACT-2 from Santa Cruz Biotechnology
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PHKA1 Lentiviral Activation Particles (h) - sc-410935-LAC from Santa Cruz Biotechnology
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PHKA1 Lentiviral Activation Particles (h2) - sc-410935-LAC-2 from Santa Cruz Biotechnology
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PHKA1 siRNA (h) - sc-91054 from Santa Cruz Biotechnology
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PHKA1 shRNA Plasmid (h) - sc-91054-SH from Santa Cruz Biotechnology
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PHKA1 shRNA (h) Lentiviral Particles - sc-91054-V from Santa Cruz Biotechnology
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PHKA1 RNAi - H00005255-R02 from Novus Biologicals
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MISSION® esiRNA - EHU113571 from Sigma-Aldrich
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MISSION® siRNA - SIHK1607 from Sigma-Aldrich
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MISSION® siRNA - SIHK1610 from Sigma-Aldrich
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MISSION® siRNA - SIHK1608 from Sigma-Aldrich
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MISSION® siRNA - SIHK1609 from Sigma-Aldrich
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MISSION® siRNA - SIHK1612 from Sigma-Aldrich
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MISSION® siRNA - SIHK1611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16739 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16739 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02986 from Sigma-Aldrich
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PHKA1 siRNA (Human) - CRH3508 from Cohesion Biosciences
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shRNA set against Human PHKA1 (NM_002637.3) - SHH374868 from Creative biogene
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Human PHKA1 siRNA - orb264010 from Biorbyt
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