VHL

Gene Symbol VHL
Entrez Gene 7428
Alt Symbol HRCA1, RCA1, VHL1, pVHL
Species Human
Gene Type protein-coding
Description von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Other Description elongin binding protein|protein G7|von Hippel-Lindau disease tumor suppressor
Swissprots P40337 Q13599 Q6PDA9 B2RE45
Accessions AAA98614 AAB64200 ABP65324 AFM52329 AFS51418 CAA65343 CAB50862 CAB50863 CBX47504 CBX47505 EAW64064 EAW64065 EAW64066 EAW64067 EAW64068 P40337 AA361862 AF088066 AK304002 BAG64919 AK309560 AK315799 BAG38142 AW022843 BC027957 AAH27957 BC058831 AAH58831 BG284971 BG288777 BG914051 BM564781 BX100230 D58014 L15409 XM_011534078 XP_011532380 NM_000551 NP_000542 NM_198156 NP_937799
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355}.
Subcellular Location Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.
Tissue Specificity Expressed in the adult and fetal brain and kidney.
Top Pathways Ubiquitin mediated proteolysis, Renal cell carcinoma

VHL-Over-expression-Lysate - LY15859a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag VHL (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the VHL gene‘

VHL 293T Cell Transient Overexpression Lysate(Denatured) - H00007428-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

VHL overexpression lysate - LY404985 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

VHL 293 Cell Lysate - 400260 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Disease Tumor

Von Hippel Lindau Overexpression Lysate (Denatured) - H00007428-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
VHL transfected lysate.

Von Hippel Lindau Overexpression Lysate (Native) - NBL1-17719 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Von Hippel Lindau Overexpression Lysate (Adult Normal) [NBL1-17719] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Von Hippel Lindau.

VHL Over-expression Lysate Product - GWB-AA07EB from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human VHL Knockdown Stable Cell Line - CSC-DC017274 from Creative biogene

Category Cell Line
Species Human
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