VHL

Gene Symbol VHL
Entrez Gene 7428
Alt Symbol HRCA1, RCA1, VHL1, pVHL
Species Human
Gene Type protein-coding
Description von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Other Description elongin binding protein|protein G7|von Hippel-Lindau disease tumor suppressor
Swissprots P40337 Q13599 Q6PDA9 B2RE45
Accessions AAA98614 AAB64200 ABP65324 AFM52329 AFS51418 CAA65343 CAB50862 CAB50863 CBX47504 CBX47505 EAW64064 EAW64065 EAW64066 EAW64067 EAW64068 P40337 AA361862 AF088066 AK304002 BAG64919 AK309560 AK315799 BAG38142 AW022843 BC027957 AAH27957 BC058831 AAH58831 BG284971 BG288777 BG914051 BM564781 BX100230 D58014 L15409 XM_011534078 XP_011532380 NM_000551 NP_000542 NM_198156 NP_937799
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355}.
Subcellular Location Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.
Tissue Specificity Expressed in the adult and fetal brain and kidney.
Top Pathways Ubiquitin mediated proteolysis, Renal cell carcinoma

VHL Antibody - 2738 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from various cell lines using VHL antibody.

VHL (FL-181) - sc-5575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VHL (FL-181): sc-5575. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing membrane and cytoplasmic staining.

VHL (G-7) - sc-17780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VHL (G-7): sc-17780. Western blot analysis of VHL expression in F9 whole cell lysate.

VHL (VHL40) - sc-135657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VHL (VHL40): sc-135657. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and membrane staining of glandular cells.

VHL (N-14) - sc-100233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

VHL (C-13) - sc-100232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Von Hippel Lindau antibody - ab110913 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab110913 at 1/50 dilution staining Von Hippel Lindau in paraffin-embedded Human Brain tissue by Immunohistochemistry. The picture on the right is treated with the synthesized peptide.

Anti-Von Hippel Lindau antibody - ab28434 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Von Hippel Lindau antibody - ab89643 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Von Hippel Lindau antibody (ab89643) at 1 µg/ml + Human placenta tissue lysate at 50 µg

Anti-Von Hippel Lindau antibody - ab117636 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab116367, at 5 µg/ml, staining Von Hippel Lindau in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.

Anti-Von Hippel Lindau antibody [1E1] - ab140989 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E1
All lanes : Anti-Von Hippel Lindau antibody [1E1] (ab140989) at 1/4000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY VHL cDNALysates/proteins at 5 µg per lane.

Anti-Von Hippel Lindau antibody [3F391] - ab11189 from Abcam

Prices $376.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 3F391

Anti-Von Hippel Lindau antibody [3F391] - ab11191 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3F391

Anti-Von Hippel Lindau antibody [52A11] - ab115496 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 52A11
ab115496, at 15 µg/ml, staining Von Hippel Lindau in formalin-fixed, paraffin-embedded Human Pancreas tissue by Immunohistochemistry using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Von Hippel Lindau antibody [52A11] - ab37268 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 52A11

Anti-Von Hippel Lindau antibody [SPM324], prediluted - ab17768 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM324
Human ovarian carcinoma stained with ab17768.

Anti-Von Hippel Lindau antibody - N-terminal - ab135576 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Von Hippel Lindau antibody - N-terminal (ab135576) at 1/50 dilution + HepG2 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-VHL / Von Hippel Lindau Antibody (HRP) - LS-C142814 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VHL / Von Hippel Lindau Antibody (DY550) - LS-C142815 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VHL / Von Hippel Lindau Antibody (aa34-83) IHC-plus™ - LS-B5361 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-VHL antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5361 concentration 5 ug/ml.

Anti-VHL / Von Hippel Lindau Antibody (Biotin) - LS-C142816 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-VHL / Von Hippel Lindau Antibody (DY650) - LS-C142817 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-VHL / Von Hippel Lindau Antibody (DY488) - LS-C142818 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-VHL / Von Hippel Lindau Antibody (HRP) - LS-C142819 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-VHL / Von Hippel Lindau Antibody (DY550) - LS-C142820 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Search more