VHL

Gene Symbol VHL
Entrez Gene 7428
Alt Symbol HRCA1, RCA1, VHL1, pVHL
Species Human
Gene Type protein-coding
Description von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Other Description elongin binding protein|protein G7|von Hippel-Lindau disease tumor suppressor
Swissprots P40337 Q13599 Q6PDA9 B2RE45
Accessions AAA98614 AAB64200 ABP65324 AFM52329 AFS51418 CAA65343 CAB50862 CAB50863 CBX47504 CBX47505 EAW64064 EAW64065 EAW64066 EAW64067 EAW64068 P40337 AA361862 AF088066 AK304002 BAG64919 AK309560 AK315799 BAG38142 AW022843 BC027957 AAH27957 BC058831 AAH58831 BG284971 BG288777 BG914051 BM564781 BX100230 D58014 L15409 XM_011534078 XP_011532380 NM_000551 NP_000542 NM_198156 NP_937799
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355}.
Subcellular Location Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.
Tissue Specificity Expressed in the adult and fetal brain and kidney.
Top Pathways Ubiquitin mediated proteolysis, Renal cell carcinoma

VHL CRISPR/Cas9 KO Plasmid (h) - sc-400528 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL HDR Plasmid (h) - sc-400528-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL Double Nickase Plasmid (h) - sc-400528-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL Double Nickase Plasmid (h2) - sc-400528-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL CRISPR Activation Plasmid (h) - sc-400528-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL CRISPR Activation Plasmid (h2) - sc-400528-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL Lentiviral Activation Particles (h) - sc-400528-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL Lentiviral Activation Particles (h2) - sc-400528-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VHL siRNA (h) - sc-36816 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VHL shRNA Plasmid (h) - sc-36816-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VHL shRNA (h) Lentiviral Particles - sc-36816-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Von Hippel Lindau RNAi - H00007428-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Von Hippel Lindau RNAi - H00007428-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU074571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1744 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1744 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

VHL siRNA (Human) - CRH5082 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VHL - MBS8216232 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human VHL (NM_000551.3) - SHH442716 from Creative biogene

Category siRNA
Species Reactivities Human

Human VHL siRNA - orb265584 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VHL shRNA Plasmid (Human) - CHH5082 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VHL miRNA 3'UTR clone - MiUTR4H-TG09762 from Creative biogene

Species Reactivities Human
Search more