VHL

Gene Symbol	VHL
Entrez Gene	7428
Alt Symbol	HRCA1, RCA1, VHL1, pVHL
Species	Human
Gene Type	protein-coding
Description	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Other Description	elongin binding protein|protein G7|von Hippel-Lindau disease tumor suppressor
Swissprots	P40337 Q13599 Q6PDA9 B2RE45
Accessions	AAA98614 AAB64200 ABP65324 AFM52329 AFS51418 CAA65343 CAB50862 CAB50863 CBX47504 CBX47505 EAW64064 EAW64065 EAW64066 EAW64067 EAW64068 P40337 AA361862 AF088066 AK304002 BAG64919 AK309560 AK315799 BAG38142 AW022843 BC027957 AAH27957 BC058831 AAH58831 BG284971 BG288777 BG914051 BM564781 BX100230 D58014 L15409 XM_011534078 XP_011532380 NM_000551 NP_000542 NM_198156 NP_937799
Function	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355}.
Subcellular Location	Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.
Tissue Specificity	Expressed in the adult and fetal brain and kidney.
Top Pathways	Ubiquitin mediated proteolysis, Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Von Hippel Lindau full length protein - ab82240 from Abcam Category Protein Source Baculovirus Species Human

Human Von Hippel Lindau peptide - ab92662 from Abcam Category Peptide

Human Von Hippel Lindau protein fragment - ab48702 from Abcam Category Protein Source E. coli Species Human

VHL / Von Hippel Lindau Antibody Blocking Peptide - LS-E8279 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VHL / Von Hippel Lindau Antibody Blocking Peptide - LS-E8280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VHL / Von Hippel Lindau Antibody Blocking Peptide - LS-E21718 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VHL / Von Hippel Lindau Antibody Blocking Peptide - LS-E26135 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Von Hippel Lindau Recombinant Protein - H00007428-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Von Hippel Lindau Protein - NBC1-18497 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

VHL-Antibody-C-term-Blocking-Peptide - BP6549b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VHL-Antibody-N-term-Blocking-Peptide - BP6549a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Von Hippel Lindau blocking peptide - GTX89268-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

VHL Protein (OPPA01350) - OPPA01350 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human VHL protein - orb81467 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Species Human

VHL Blocking Peptide - 33R-2312 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VHL protein, betadomain protein (His tag) - 80R-1008 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

Von Hippel Lindau Peptide - AC21-0965-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

VHL (1-154, His-tag) - SA6057 from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

VHL (1-154, His-tag) - SA6057X from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

VHL - H00007428-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VHL - H00007428-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Von Hippel-Lindau Protein, Human Recombinant - 228-11633-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human VHL - 228-11633-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human VHL - 228-11633-3 from RayBiotech Category Protein Prices $1,950.00 Sizes 3 µg Source Escherichia Coli. Species Human

VHL protein (beta-domain : 1-154aa), His-tag, Human Recombinant, E.coli - 01-2228 from ARP American Research Products Category Protein Prices $139.00, $299.00, $639.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

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