ZC3H8

Gene Symbol ZC3H8
Entrez Gene 84524
Alt Symbol Fliz1, ZC3HDC8
Species Human
Gene Type protein-coding
Description zinc finger CCCH-type containing 8
Other Description zinc finger CCCH domain-containing protein 8|zinc finger CCCH type domain containing 8|zinc finger CCCH-type domain containing 8
Swissprots Q9BZ75 Q8N5P1
Accessions AAY14855 AAY24050 EAW52103 Q8N5P1 AF334161 AAK13496 AK315329 BC032001 AAH32001 BG773518 CV574571 HQ448678 ADQ33156 XM_005263826 XP_005263883 XM_011511998 XP_011510300 NM_032494 NP_115883
Function Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Anti-ZC3H8 antibody - ab97821 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ZC3H8 antibody (ab97821) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : HepG2 whole cell lysateLane 3 : Raji whole cell lysate

Anti-ZC3H8 antibody - ab113260 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ZC3H8 antibody (ab113260) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-ZC3H8 antibody - N-terminal - ab170393 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram) labeling ZC3H8 with ab170393 at 1/10 dilution. FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Anti-ZC3H8 Antibody (aa52-81, AP) - LS-C224702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa52-81, APC) - LS-C224703 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa52-81, Biotin) - LS-C224704 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa52-81, Azide-free, HRP) - LS-C224706 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa52-81, FITC) - LS-C224705 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa52-81, PE) - LS-C224707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa1-50) - LS-C289790 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa50-100) - LS-C289791 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa59-90) - LS-C326463 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa133-178) - LS-C313801 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (aa74-123) - LS-C292218 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZC3H8 Antibody (clone 3G10) - LS-C340492 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZC3H8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ZC3H8 (1:2000).

Anti-ZC3H8 Antibody (aa52-81) - LS-C160740 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ZC3H8 Antibody western blot of mouse Neuro-2a cell line lysates (35 ug/lane). The ZC3H8 antibody detected the ZC3H8 protein (arrow).

Anti-ZC3H8 Antibody (clone 9F11) - LS-C340464 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9F11
IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-ZC3H8 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150).

Anti-ZC3H8 Antibody (aa31-291) - LS-C185854 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded NCIN87 xenograft using ZC3H8 antibody at 1:500 dilution.

Anti-ZC3H8 Antibody (aa81-130) IHC-plus™ - LS-B8598 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ZC3H8 antibody IHC of human lung, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8598 dilution 5 ug/ml.

ZC3H8 Antibody - NBP1-84661 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ZC3H8 Antibody [NBP1-84661] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

ZC3H8 Antibody - NBP1-32522 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ZC3H8 Antibody [NBP1-32522] - Sample(30 ug whole cell lysate)A:A431 B:Hep G2 C:Raji 12% SDS PAGE, antibody diluted at 1:1000.

ZC3H8 Antibody - NBP2-33980 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ZC3H8 Antibody [NBP2-33980] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: MOLT-4

Anti-ZC3H8 antibody produced in rabbit - SAB2702017 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ZC3H8: <B>Cat. No. SAB2702017</B>: Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using ZC3H8 antibody at a 1:500 dilution.

Anti-ZC3H8 (141-155) antibody produced in rabbit - SAB1103106 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells was separated on SDS-PAGE, blotted with Anti-ZC3H8 (141-155) (<B>Cat. No. SAB1103106</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500

Anti-ZC3H8 antibody produced in rabbit - HPA034803 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ZC3H8: <B>Cat. No. HPA034803</B>: Immunohistochemical staining of Human cerebral cortex shows strong nuclear positivity in neuronal cells.
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