ZC3H8

Gene Symbol ZC3H8
Entrez Gene 84524
Alt Symbol Fliz1, ZC3HDC8
Species Human
Gene Type protein-coding
Description zinc finger CCCH-type containing 8
Other Description zinc finger CCCH domain-containing protein 8|zinc finger CCCH type domain containing 8|zinc finger CCCH-type domain containing 8
Swissprots Q9BZ75 Q8N5P1
Accessions AAY14855 AAY24050 EAW52103 Q8N5P1 AF334161 AAK13496 AK315329 BC032001 AAH32001 BG773518 CV574571 HQ448678 ADQ33156 XM_005263826 XP_005263883 XM_011511998 XP_011510300 NM_032494 NP_115883
Function Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Fliz1 CRISPR/Cas9 KO Plasmid (h) - sc-413659 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 HDR Plasmid (h) - sc-413659-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 Double Nickase Plasmid (h) - sc-413659-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 Double Nickase Plasmid (h2) - sc-413659-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 CRISPR Activation Plasmid (h) - sc-413659-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 CRISPR Activation Plasmid (h2) - sc-413659-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 Lentiviral Activation Particles (h) - sc-413659-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 Lentiviral Activation Particles (h2) - sc-413659-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fliz1 siRNA (h) - sc-94586 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fliz1 shRNA Plasmid (h) - sc-94586-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fliz1 shRNA (h) Lentiviral Particles - sc-94586-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZC3H8 RNAi - H00084524-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU137561 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23107 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06020 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06020

ZC3H8 siRNA (Human) - CRJ3508 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZC3H8 - MBS8228368 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ZC3H8 (NM_032494.2) - SHH449516 from Creative biogene

Category siRNA
Species Reactivities Human

ZC3H8 shRNA Plasmid (Human) - CHJ3508 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ZC3H8 miRNA 3'UTR clone - MiUTR3H-16637 from Creative biogene

Species Reactivities Human
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