| Gene Symbol |
ZC3H8
|
| Entrez Gene |
84524
|
| Alt Symbol |
Fliz1, ZC3HDC8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger CCCH-type containing 8
|
| Other Description |
zinc finger CCCH domain-containing protein 8|zinc finger CCCH type domain containing 8|zinc finger CCCH-type domain containing 8
|
| Swissprots |
Q9BZ75 Q8N5P1
|
| Accessions |
AAY14855 AAY24050 EAW52103 Q8N5P1 AF334161 AAK13496 AK315329 BC032001 AAH32001 BG773518 CV574571 HQ448678 ADQ33156 XM_005263826 XP_005263883 XM_011511998 XP_011510300 NM_032494 NP_115883
|
| Function |
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
|