CPLX2

Gene Symbol CPLX2
Entrez Gene 10814
Alt Symbol 921-L, CPX-2, CPX2, Hfb1
Species Human
Gene Type protein-coding
Description complexin 2
Other Description CPX II|complexin II|complexin-2|synaphin 1|synaphin-1
Swissprots Q52M15 B2RAG2 Q6PUV4
Accessions EAW61366 EAW61367 Q6PUV4 AK055043 AK094266 AK124837 AK126590 AK293819 BAG57224 AK314177 BAG36859 AL512758 AL707430 AY576870 AAS93622 BC039560 BC052974 BC065485 BC093706 AAH93706 BC112287 AAI12288 BI197868 BN000499 CAG26663 BN000500 CAG26664 U35100 AAC50229 Y15167 XM_005265798 XP_005265855 XM_005265799 XP_005265856 XM_011534419 XP_011532721 NM_001008220 NP_001008221 NM_006650 NP_006641
Function Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:11576753, ECO:0000269|PubMed:15906159, ECO:0000269|PubMed:16162394, ECO:0000269|PubMed:9853440}.
Top Pathways Synaptic vesicle cycle

CPLX2-Over-expression-Lysate - LY10874a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CPLX2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CPLX2 gene

CPLX2 overexpression lysate - LY423397 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CPLX2 293 Cell Lysate - 409930 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Complexin-2 Overexpression Lysate (Native) - NBL1-09436 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: CPLX2 Overexpression Lysate (Adult Normal) [NBL1-09436] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CPLX2.

Complexin-2 Overexpression Lysate (Native) - NBP2-07597 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

CPLX2 Over-expression Lysate Product - GWB-98771C from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Complexin-2 Overexpression Lysate (Native) - NBP2-09835 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: CPLX2 Overexpression Lysate (Adult Normal) [NBP2-09835] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CPLX2.

Panoply™ Human CPLX2 Knockdown Stable Cell Line - CSC-DC003569 from Creative biogene

Category Cell Line
Species Human
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