CPLX2

Gene Symbol	CPLX2
Entrez Gene	10814
Alt Symbol	921-L, CPX-2, CPX2, Hfb1
Species	Human
Gene Type	protein-coding
Description	complexin 2
Other Description	CPX II|complexin II|complexin-2|synaphin 1|synaphin-1
Swissprots	Q52M15 B2RAG2 Q6PUV4
Accessions	EAW61366 EAW61367 Q6PUV4 AK055043 AK094266 AK124837 AK126590 AK293819 BAG57224 AK314177 BAG36859 AL512758 AL707430 AY576870 AAS93622 BC039560 BC052974 BC065485 BC093706 AAH93706 BC112287 AAI12288 BI197868 BN000499 CAG26663 BN000500 CAG26664 U35100 AAC50229 Y15167 XM_005265798 XP_005265855 XM_005265799 XP_005265856 XM_011534419 XP_011532721 NM_001008220 NP_001008221 NM_006650 NP_006641
Function	Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity	Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:11576753, ECO:0000269|PubMed:15906159, ECO:0000269|PubMed:16162394, ECO:0000269|PubMed:9853440}.
Top Pathways	Synaptic vesicle cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CPLX2 peptide - ab197143 from Abcam Category Peptide

CPLX2 / Complexin 2 Antibody Blocking Peptide - LS-E18764 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Human Complexin 2 protein - orb84327 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Complexin 2 Blocking Peptide - 33R-5832 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Complexin 2 Protein - abx066089 from Abbexa Category Protein Source E.coli Species Human

Complexin 2 (CPLX2), Human - 20-9054 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Human

CPLX2 fusion protein - Ag12838 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CPLX2, His tagged - CPLX2-3941H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CPLX2, GST-tagged - CPLX2-11520H from Creative Biomart Category Protein Source E.coli Species Human

CPLX2 - PN201447 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source E. coli Species Human

Recombinant Complexin 2 (CPLX2) - RPF332Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Complexin 2 (CPLX2) - RPF332Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Human Complexin-2 / CPLX2 Protein (His Tag) - 11927-H07E-100 from Sino Biological Category Protein Source E. coli Species Human

Recombinant Complexin 2 (CPLX2) - RPF332Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Complexin-2(CPLX2) - CSB-YP761369HU CSB-EP761369HU CSB-BP761369HU CSB-MP761369HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Complexin 2 (CPLX2) - RPU140979 from Biomatik Category Protein Prices $209.00, $418.00, $627.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

CPLX2 Protein - abx164459 from Abbexa Category Protein Species Human, Mouse, Rat

Complexin-2 (transcript variant 1) - TP310806 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Complexin-2 (transcript variant 2) - TP321947 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Complexin-2 (full length, C-term DDK tag, transcript variant 1) - TP710112 from Acris Antibodies Category Protein Prices $399.00 Sizes 20 µg Source SF9 cells Species Human

Recombinant Human Complexin-2 / CPLX2 Protein (His tag) - PKSH030970 from Elabscience Category Protein Source E. coli Species Human

CPLX2-Blocking-Peptide-Center - BP20736c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CPLX2-Blocking-Peptide-Center - BP20735c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CPLX2 Peptide, Human - M34GP03569H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human CPLX2 protein - orb54288 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

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