| Gene Symbol | HOOK2 |
|---|---|
| Entrez Gene | 29911 |
| Alt Symbol | HK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hook microtubule-tethering protein 2 |
| Other Description | h-hook2|hHK2|hook homolog 2|protein Hook homolog 2 |
| Swissprots | Q96ED9 O60562 |
| Accessions | EAW84305 EAW84306 Q96ED9 AF044924 AAC09299 AK129729 BAC85229 BC012443 AAH12443 DB474423 DQ891339 ABM82265 DQ893360 ABM84286 DQ894521 ABM85447 DQ896679 ABM87678 XM_005259873 XP_005259930 XM_005259874 XP_005259931 XM_005259876 XP_005259933 XM_005259877 XP_005259934 XM_011527943 XP_011526245 XM_011527944 XP_011526246 XM_011527945 XP_011526247 XM_011527946 XP_011526248 XM_011527947 XP_011526249 NM_001100176 NP_001093646 NM_013312 NP_037444 |
| Function | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. |