| Gene Symbol |
SF3B2
|
| Entrez Gene |
10992
|
| Alt Symbol |
Cus1, SAP145, SF3B145, SF3b1, SF3b150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
splicing factor 3b, subunit 2, 145kDa
|
| Other Description |
SAP 145|pre-mRNA splicing factor SF3b 145 kDa subunit|pre-mRNA-splicing factor SF3b 145 kDa subunit|spliceosome associated protein 145|spliceosome-associated protein 145|splicing factor 3B subunit 2|splicing factor 3b, subunit 2, 145kD
|
| Swissprots |
Q7Z627 Q9BWD2 Q13435 B4DT19 A8K485 Q96CM6 Q969K1 Q7L4T5
|
| Accessions |
EAW74491 EAW74492 EAW74493 EAW74494 EAW74495 EAW74496 EAW74497 EAW74498 EAW74499 EAW74500 EAW74501 Q13435 AK092510 AK126488 AK290850 BAF83539 AK300016 BAG61831 BC000401 AAH00401 BC007610 AAH07610 BC014125 AAH14125 BC051237 BC053577 AAH53577 BE677116 BF311442 BX537771 CAD97834 JF432116 ADZ15333 U41371 AAA97461 XM_005273726 XP_005273783 XM_011544740 XP_011543042 NM_006842 NP_006833
|
| Function |
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Spliceosome
|
![Western Blot: SF3B2 Overexpression Lysate (Adult Normal) [NBP2-07573] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SF3B2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5754_SF3B2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07573-img0001.jpg)