| Gene Symbol |
PLK2
|
| Entrez Gene |
10769
|
| Alt Symbol |
SNK, hPlk2, hSNK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polo-like kinase 2
|
| Other Description |
PLK-2|serine/threonine-protein kinase PLK2|serine/threonine-protein kinase SNK|serum-inducible kinase
|
| Swissprots |
Q9NYY3 O60679 Q9UE61 Q96CV7
|
| Accessions |
CAS92534 CAT02199 EAW54972 EAW54973 Q9NYY3 AA469989 AA954432 AF059617 AAC14573 AF223574 AAF62897 AI655395 AK027851 AK098163 BAC05247 AK297298 BAG59766 AK304746 BAH14250 AK312505 BC013879 AAH13879 BF437296 BI559351 DA020501 DQ893653 ABM84579 DQ895830 ABM86756 N66865 U85755 AAD00575 NM_001252226 NP_001239155 NM_006622 NP_006613
|
| Function |
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
|
| Tissue Specificity |
Expressed at higher level in the fetal lung, kidney, spleen and heart. {ECO:0000269|PubMed:11696980}.
|