PLK2

Gene Symbol	PLK2
Entrez Gene	10769
Alt Symbol	SNK, hPlk2, hSNK
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 2
Other Description	PLK-2|serine/threonine-protein kinase PLK2|serine/threonine-protein kinase SNK|serum-inducible kinase
Swissprots	Q9NYY3 O60679 Q9UE61 Q96CV7
Accessions	CAS92534 CAT02199 EAW54972 EAW54973 Q9NYY3 AA469989 AA954432 AF059617 AAC14573 AF223574 AAF62897 AI655395 AK027851 AK098163 BAC05247 AK297298 BAG59766 AK304746 BAH14250 AK312505 BC013879 AAH13879 BF437296 BI559351 DA020501 DQ893653 ABM84579 DQ895830 ABM86756 N66865 U85755 AAD00575 NM_001252226 NP_001239155 NM_006622 NP_006613
Function	Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Tissue Specificity	Expressed at higher level in the fetal lung, kidney, spleen and heart. {ECO:0000269|PubMed:11696980}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PLK2 full length protein - ab102108 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PLK2 full length protein - ab42602 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PLK2 full length protein - ab153125 from Abcam Category Protein Source Wheat germ Species Human

Human PLK2 full length protein - ab153126 from Abcam Category Protein Source Wheat germ Species Human

Human PLK2 peptide - ab27819 from Abcam Category Peptide

Human PLK2 protein fragment - ab153127 from Abcam Category Protein Source Wheat germ Species Human

SNK / PLK2 Antibody Blocking Peptide - LS-E2955 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNK / PLK2 Antibody Blocking Peptide - LS-E8801 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNK / PLK2 Antibody Blocking Peptide - LS-E18756 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PLK2 Protein - H00010769-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PLK2 Protein - H00010769-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PLK2 Protein - H00010769-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PLK2 Recombinant Protein - P4776 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PLK2 Peptide - P2434 from Novus Biologicals Category Peptide Species Human

SNK-Antibody-Center-K390-Blocking-Peptide - BP18959c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLK2-SNK-Antibody-C-term-Blocking-peptide - BP7252a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLK2 / SNK - H00010769-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PLK2 / SNK - H00010769-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PLK2 / SNK - H00010769-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PLK2 / SNK - H00010769-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PLK2 / SNK - H00010769-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PLK2 / SNK - H00010769-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLK2 / SNK - H00010769-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLK2 / SNK - P4776 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PLK2 / SNK - P5797 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

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