PLK2

Gene Symbol PLK2
Entrez Gene 10769
Alt Symbol SNK, hPlk2, hSNK
Species Human
Gene Type protein-coding
Description polo-like kinase 2
Other Description PLK-2|serine/threonine-protein kinase PLK2|serine/threonine-protein kinase SNK|serum-inducible kinase
Swissprots Q9NYY3 O60679 Q9UE61 Q96CV7
Accessions CAS92534 CAT02199 EAW54972 EAW54973 Q9NYY3 AA469989 AA954432 AF059617 AAC14573 AF223574 AAF62897 AI655395 AK027851 AK098163 BAC05247 AK297298 BAG59766 AK304746 BAH14250 AK312505 BC013879 AAH13879 BF437296 BI559351 DA020501 DQ893653 ABM84579 DQ895830 ABM86756 N66865 U85755 AAD00575 NM_001252226 NP_001239155 NM_006622 NP_006613
Function Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Tissue Specificity Expressed at higher level in the fetal lung, kidney, spleen and heart. {ECO:0000269|PubMed:11696980}.

Snk (A-6) - sc-390827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Snk (A-6): sc-390827. Western blot analysis of Snk expression in non-transfected: sc-117752 (A) and human Snk transfected: sc-170549 (B) 293T whole cell lysates.

Snk (E-10) - sc-374643 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Snk (E-10): sc-374643. Western blot analysis of Snk expression in T24 (A), ES-2 (B), MCF7 (C) and HISM (D) whole cell lysates.

Snk (N-17) - sc-9575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Snk (N-17): sc-9575. Western blot analysis of Snk expression in non-transfected: sc-117752 (A) and human Snk transfected: sc-170549 (B) 293T whole cell lysates.

Snk (H-90) - sc-25421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Snk (H-90): sc-25421. Immunofluorescence staining of methanol-fixed Jar cells showing membrane localization.

Snk (C-18) - sc-9577 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Snk (C-18): sc-9577. Western blot analysis of Snk expression in non-transfected 293T: sc-117752 (A) and human Snk transfected 293T: sc-170549 (B) whole cell lysates.

Anti-PLK2 antibody - ab71311 from Abcam

Prices $379.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Human breast carcinoma tissue with ab71311 at 1/50 dilution. DAB staining.

Anti-PLK2 antibody [EPR10070] - ab154794 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10070
Overlay histogram showing HeLa cells stained with ab154794 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab154794, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-PLK2 antibody - C-terminal - ab176392 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PLK2 antibody - C-terminal (ab176392) at 0.5 µg/mlLane 1 : A431 cell lysateLane 2 : 293T cell lysateLane 3 : COLO320 cell lysate

Anti-SNK / PLK2 Antibody (aa354-382, AP) - LS-C216839 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa354-382, APC) - LS-C216840 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa279-328) - LS-C200499 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using PLK2 antibody.

Anti-SNK / PLK2 Antibody (aa354-382, Biotin) - LS-C216841 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa354-382, FITC) - LS-C216842 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa354-382, Azide-free, HRP) - LS-C216843 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa354-382, PE) - LS-C216844 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (C-Terminus, AP) - LS-C220385 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa261-310) - LS-C145774 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PLK2 antibody LS-C145774 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-SNK / PLK2 Antibody (C-Terminus, APC) - LS-C220386 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (C-Terminus, Biotin) - LS-C220387 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (C-Terminus, FITC) - LS-C220388 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (C-Terminus, Azide-free, HRP) - LS-C220389 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (C-Terminus, PE) - LS-C220390 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (C-Terminus) - LS-C328276 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa353-382) - LS-C324108 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNK / PLK2 Antibody (aa291-340) IHC-plus™ - LS-B9872 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SNK / PLK2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9872 concentration 10 ug/ml.
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