PLK2

Gene Symbol	PLK2
Entrez Gene	10769
Alt Symbol	SNK, hPlk2, hSNK
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 2
Other Description	PLK-2|serine/threonine-protein kinase PLK2|serine/threonine-protein kinase SNK|serum-inducible kinase
Swissprots	Q9NYY3 O60679 Q9UE61 Q96CV7
Accessions	CAS92534 CAT02199 EAW54972 EAW54973 Q9NYY3 AA469989 AA954432 AF059617 AAC14573 AF223574 AAF62897 AI655395 AK027851 AK098163 BAC05247 AK297298 BAG59766 AK304746 BAH14250 AK312505 BC013879 AAH13879 BF437296 BI559351 DA020501 DQ893653 ABM84579 DQ895830 ABM86756 N66865 U85755 AAD00575 NM_001252226 NP_001239155 NM_006622 NP_006613
Function	Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Tissue Specificity	Expressed at higher level in the fetal lung, kidney, spleen and heart. {ECO:0000269|PubMed:11696980}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Snk CRISPR/Cas9 KO Plasmid (h) - sc-417379 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk HDR Plasmid (h) - sc-417379-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk Double Nickase Plasmid (h) - sc-417379-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk Double Nickase Plasmid (h2) - sc-417379-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk CRISPR Activation Plasmid (h) - sc-417379-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk CRISPR Activation Plasmid (h2) - sc-417379-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk Lentiviral Activation Particles (h) - sc-417379-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk Lentiviral Activation Particles (h2) - sc-417379-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Snk siRNA (h) - sc-39152 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Snk shRNA Plasmid (h) - sc-39152-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Snk shRNA (h) Lentiviral Particles - sc-39152-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Snk siRNA (h2) - sc-156159 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Snk shRNA Plasmid (h2) - sc-156159-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Snk shRNA (h2) Lentiviral Particles - sc-156159-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU021811 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1745 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1746 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1744 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2352 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2352 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04857 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04857

PLK2 siRNA (Human) - CRH7338 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PLK2 RNAi - H00010769-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PLK2 (NM_006622.3) - SHH377904 from Creative biogene Category siRNA Species Reactivities Human

PLK2 shRNA Plasmid (Human) - CHH7338 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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