Gene Symbol | SHROOM2 |
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Entrez Gene | 357 |
Alt Symbol | APXL, HSAPXL |
Species | Human |
Gene Type | protein-coding |
Description | shroom family member 2 |
Other Description | APX homolog of Xenopus|apical-like protein|protein Shroom2 |
Swissprots | Q13796 B9EIQ7 |
Accessions | AAC32592 EAW98774 Q13796 AK096596 BAG53335 AK299907 BAH13168 BC140866 AAI40867 CR749271 CAH18127 X83543 CAA58534 XM_005274500 XP_005274557 XM_011545506 XP_011543808 NM_001649 NP_001640 |
Function | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
Subcellular Location | Apical cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with cortical F-actin. {ECO:0000250}. |
Tissue Specificity | Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas. |
Top Pathways | Tight junction |
APXL CRISPR/Cas9 KO Plasmid (h) - sc-410690 from Santa Cruz Biotechnology
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APXL HDR Plasmid (h) - sc-410690-HDR from Santa Cruz Biotechnology
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APXL Double Nickase Plasmid (h) - sc-410690-NIC from Santa Cruz Biotechnology
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APXL Double Nickase Plasmid (h2) - sc-410690-NIC-2 from Santa Cruz Biotechnology
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APXL CRISPR Activation Plasmid (h) - sc-410690-ACT from Santa Cruz Biotechnology
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APXL CRISPR Activation Plasmid (h2) - sc-410690-ACT-2 from Santa Cruz Biotechnology
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APXL Lentiviral Activation Particles (h) - sc-410690-LAC from Santa Cruz Biotechnology
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APXL Lentiviral Activation Particles (h2) - sc-410690-LAC-2 from Santa Cruz Biotechnology
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APXL siRNA (h) - sc-72525 from Santa Cruz Biotechnology
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APXL shRNA Plasmid (h) - sc-72525-SH from Santa Cruz Biotechnology
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APXL shRNA (h) Lentiviral Particles - sc-72525-V from Santa Cruz Biotechnology
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APXL RNAi - H00000357-R01 from Novus Biologicals
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MISSION® esiRNA - EHU032831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19316 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19316 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12930 from Sigma-Aldrich
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SHROOM2 siRNA (Human) - CRH0253 from Cohesion Biosciences
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SHROOM2 - MBS8219722 from MyBioSource
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shRNA set against Human SHROOM2 (NM_001649.2) - SHH407276 from Creative biogene
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shRNA set against Human SHROOM2(NM_001649.2) - SHR224588 from Creative biogene
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SHROOM2 shRNA Plasmid (Human) - CHH0253 from Cohesion Biosciences
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SHROOM2 miRNA 3'UTR clone - MiUTR1H-09386 from Creative biogene
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