Gene Symbol | LTK |
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Entrez Gene | 4058 |
Alt Symbol | TYK1 |
Species | Human |
Gene Type | protein-coding |
Description | leukocyte receptor tyrosine kinase |
Other Description | leukocyte tyrosine kinase receptor|protein tyrosine kinase 1 |
Swissprots | A6NNJ8 B4DL89 E9PFX4 P29376 |
Accessions | CAM91186 EAW92494 EAW92495 EAW92496 EAW92497 EAW92498 EAW92499 EAW92500 EAW92501 P29376 AK296892 BAG59451 AK314006 BC045607 AAH45607 BC143903 BX329448 CA394397 D16105 BAA03679 DA452723 DB331746 X52213 CAA36460 X60702 CAA43113 XM_011521556 XP_011519858 XM_011521557 XP_011519859 XM_011521558 XP_011519860 NM_001135685 NP_001129157 NM_002344 NP_002335 NM_206961 NP_996844 |
Function | Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. {ECO:0000269|PubMed:20548102}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in non-hematopoietic cell lines and T- and B-cell lines. {ECO:0000269|PubMed:2156206}. |
Active human LTK protein fragment - ab179494 from Abcam
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Human LTK protein fragment - ab158835 from Abcam
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LTK Antibody Blocking Peptide - LS-E3020 from LifeSpan Bioscience
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LTK Antibody Blocking Peptide - LS-E22064 from LifeSpan Bioscience
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LTK Antibody Blocking Peptide - LS-E9161 from LifeSpan Bioscience
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Recombinant Human LTK Protein - H00004058-Q01 from Novus Biologicals
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LTK Peptide - P2692 from Novus Biologicals
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LTK-Antibody-N-term-Blocking-Peptide - BP7658a from Abgent, a WuXi AppTec company
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LTK Blocking Peptide - 33R-3281 from Fitzgerald
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LTK / TYK1 - H00004058-Q01-10 from Acris Antibodies
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LTK / TYK1 - H00004058-Q01-25 from Acris Antibodies
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LTK / TYK1 - P5581 from Acris Antibodies
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LTK (R241) Peptide - BS2267P from Bioworld Technology
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Recombinant Human Leukocyte tyrosine kinase receptor(LTK) - CSB-YP013230HU CSB-EP013230HU CSB-BP013230HU CSB-MP013230HU from Cusabio
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LTK / TYK1 (C-term DDK/His tag) - TP700153 from Acris Antibodies
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LTK / TYK1 (C-term DDK tag, transcript variant 1) - TP710164 from Acris Antibodies
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LTK Recombinant Protein Antigen - NBP2-32475PEP from Novus Biologicals
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LTK Blocking Peptide - abx061057 from Abbexa
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LTK-Antibody-C-term-Blocking-Peptide - BP7658b from Abgent, a WuXi AppTec company
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LTK Peptide, Human - M34GP08987H from Creative Peptides
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LTK Blocking Peptide - CBP4970 from Cohesion Biosciences
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Recombinant Human LTK Protein, CF - 9376-LK from R&D Systems
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Leukocyte tyrosine kinase receptor (LTK), Recombinant Protein - MBS950831 from MyBioSource
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LTK peptide - orb319116 from Biorbyt
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