| Gene Symbol |
NOX1
|
| Entrez Gene |
27035
|
| Alt Symbol |
GP91-2, MOX1, NOH-1, NOH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NADPH oxidase 1
|
| Other Description |
NADH/NADPH mitogenic oxidase subunit P65-MOX|NADPH oxidase homolog-1|mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)|mitogenic oxidase 1
|
| Swissprots |
Q2PP02 O95691 Q9Y5S8 A8K836
|
| Accessions |
ABC40742 EAX02820 EAX02821 EAX02822 EAX02823 EAX02824 Q9Y5S8 AF127763 AAD38133 AF166326 AAF23232 AF166327 AAF23233 AF166328 AAF23234 AI285296 AJ438989 CAD27735 AK292201 BAF84890 AK313678 BC075014 AAH75014 BC075015 AAH75015 BX956931 DQ424904 ABD83669 NM_001271815 NP_001258744 NM_007052 NP_008983 NM_013955 NP_039249 NM_013954
|
| Function |
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
|
| Subcellular Location |
Cell projection, invadopodium membrane {ECO:0000269|PubMed:19755710}; Multi-pass membrane protein {ECO:0000269|PubMed:19755710}.
|
| Tissue Specificity |
NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH- 1S is detected only in colon and colon carcinoma cells.
|
| Top Pathways |
Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation
|