NOX1
| Gene Symbol | NOX1 |
|---|---|
| Entrez Gene | 27035 |
| Alt Symbol | GP91-2, MOX1, NOH-1, NOH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NADPH oxidase 1 |
| Other Description | NADH/NADPH mitogenic oxidase subunit P65-MOX|NADPH oxidase homolog-1|mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)|mitogenic oxidase 1 |
| Swissprots | Q2PP02 O95691 Q9Y5S8 A8K836 |
| Accessions | ABC40742 EAX02820 EAX02821 EAX02822 EAX02823 EAX02824 Q9Y5S8 AF127763 AAD38133 AF166326 AAF23232 AF166327 AAF23233 AF166328 AAF23234 AI285296 AJ438989 CAD27735 AK292201 BAF84890 AK313678 BC075014 AAH75014 BC075015 AAH75015 BX956931 DQ424904 ABD83669 NM_001271815 NP_001258744 NM_007052 NP_008983 NM_013955 NP_039249 NM_013954 |
| Function | NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. |
| Subcellular Location | Cell projection, invadopodium membrane {ECO:0000269|PubMed:19755710}; Multi-pass membrane protein {ECO:0000269|PubMed:19755710}. |
| Tissue Specificity | NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH- 1S is detected only in colon and colon carcinoma cells. |
| Top Pathways | Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation |
Mox1 CRISPR/Cas9 KO Plasmid (h) - sc-400951 from Santa Cruz Biotechnology
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Mox1 HDR Plasmid (h) - sc-400951-HDR from Santa Cruz Biotechnology
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Mox1 Double Nickase Plasmid (h) - sc-400951-NIC from Santa Cruz Biotechnology
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Mox1 Double Nickase Plasmid (h2) - sc-400951-NIC-2 from Santa Cruz Biotechnology
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Mox1 CRISPR Activation Plasmid (h) - sc-400951-ACT from Santa Cruz Biotechnology
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Mox1 CRISPR Activation Plasmid (h2) - sc-400951-ACT-2 from Santa Cruz Biotechnology
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Mox1 Lentiviral Activation Particles (h) - sc-400951-LAC from Santa Cruz Biotechnology
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Mox1 Lentiviral Activation Particles (h2) - sc-400951-LAC-2 from Santa Cruz Biotechnology
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Mox1 siRNA (h) - sc-43939 from Santa Cruz Biotechnology
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Mox1 shRNA Plasmid (h) - sc-43939-SH from Santa Cruz Biotechnology
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Mox1 shRNA (h) Lentiviral Particles - sc-43939-V from Santa Cruz Biotechnology
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NOX1 RNAi - H00027035-R01 from Novus Biologicals
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NOX1 RNAi - H00027035-R02 from Novus Biologicals
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MISSION® esiRNA - EHU076051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15428 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15428 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05437 from Sigma-Aldrich
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NOX1 siRNA (Human) - CRH8933 from Cohesion Biosciences
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NOX1 RNAi - H00027035-R03 from Novus Biologicals
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shRNA set against Human NOX1 (NM_007052.4) - SHH353925 from Creative biogene
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shRNA set against Human NOX1(NM_007052.4) - SHR016472 from Creative biogene
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shRNA set against Human NOX1(NM_013955.2) - SHR016804 from Creative biogene
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shRNA set against Human NOX1(NM_007052.4) - SHR016822 from Creative biogene
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NOX1 shRNA Plasmid (Human) - CHH8933 from Cohesion Biosciences
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NOX1 miRNA 3'UTR clone - MiUTR1H-06861 from Creative biogene
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