| Gene Symbol |
TTF2
|
| Entrez Gene |
8458
|
| Alt Symbol |
HuF2, ZGRF6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription termination factor, RNA polymerase II
|
| Other Description |
F2|RNA polymerase II termination factor|human factor 2|lodestar homolog|lodestar protein|transcription release factor 2|transcription termination factor 2|zinc finger, GRF-type containing 6
|
| Swissprots |
Q9UNY4 O75921 Q8N6I8 Q5VVU8 Q5T2K7 A8K4Q2
|
| Accessions |
EAW56666 EAW56667 Q9UNY4 AB209845 BAD93082 AF073771 AAC64044 AF080255 AAD49435 AI991355 AK291017 BAF83706 AW027795 BC015341 BC030058 AAH30058 BI857056 BQ422564 BU182600 H81916 XM_005271277 XP_005271334 XM_006710979 XP_006711042 XM_006710980 XP_006711043 XM_006710981 XP_006711044 XM_011542303 XP_011540605 XM_011542304 XP_011540606 XM_011542305 XP_011540607 XR_946782 NM_003594 NP_003585
|
| Function |
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15125840}. Nucleus {ECO:0000269|PubMed:15125840}. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
|
| Top Pathways |
Thyroid hormone synthesis
|