| Gene Symbol | BRSK1 |
|---|---|
| Entrez Gene | 84446 |
| Alt Symbol | hSAD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BR serine/threonine kinase 1 |
| Other Description | BR serine/threonine-protein kinase 1|SAD1 homolog|SAD1 kinase|SadB kinase short isoform|brain-selective kinase 1|brain-specific serine/threonine-protein kinase 1|protein kinase SAD1A|serine/threonine-protein kinase BRSK1|serine/threonine-protein kinase SAD-B|synapses of Amphids Defective homolog 1 |
| Swissprots | Q96JL4 Q5J5B5 F1DG44 Q96AV4 Q8TDC3 Q8TDC2 Q8NDR4 Q8NDD0 |
| Accessions | EAW72359 EAW72360 EAW72361 Q8TDC3 AB058714 BAB47440 AF479826 AAL87697 AF479827 AAL87698 AK124999 BAG54120 AL831945 CAD38595 AL834275 CAD38950 AY458602 AAS10354 AY505124 AAS86442 BC016681 AAH16681 HQ830199 ADX95745 XM_005259327 XP_005259384 XM_011527395 XP_011525697 XR_430213 NM_032430 NP_115806 |
| Function | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma- tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, pro |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localizes to synaptic vesicles in neurons (By similarity). Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS- induced DNA damage. {ECO:0000250}. |
| Tissue Specificity | Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. {ECO:0000269|PubMed:15150265}. |