BRSK1

Gene Symbol	BRSK1
Entrez Gene	84446
Alt Symbol	hSAD1
Species	Human
Gene Type	protein-coding
Description	BR serine/threonine kinase 1
Other Description	BR serine/threonine-protein kinase 1|SAD1 homolog|SAD1 kinase|SadB kinase short isoform|brain-selective kinase 1|brain-specific serine/threonine-protein kinase 1|protein kinase SAD1A|serine/threonine-protein kinase BRSK1|serine/threonine-protein kinase SAD-B|synapses of Amphids Defective homolog 1
Swissprots	Q96JL4 Q5J5B5 F1DG44 Q96AV4 Q8TDC3 Q8TDC2 Q8NDR4 Q8NDD0
Accessions	EAW72359 EAW72360 EAW72361 Q8TDC3 AB058714 BAB47440 AF479826 AAL87697 AF479827 AAL87698 AK124999 BAG54120 AL831945 CAD38595 AL834275 CAD38950 AY458602 AAS10354 AY505124 AAS86442 BC016681 AAH16681 HQ830199 ADX95745 XM_005259327 XP_005259384 XM_011527395 XP_011525697 XR_430213 NM_032430 NP_115806
Function	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma- tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, pro
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localizes to synaptic vesicles in neurons (By similarity). Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS- induced DNA damage. {ECO:0000250}.
Tissue Specificity	Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. {ECO:0000269|PubMed:15150265}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KIAA1811 / BRSK1 Antibody Blocking Peptide - LS-E21907 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIAA1811 / BRSK1 Antibody Blocking Peptide - LS-E30328 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KIAA1811 / BRSK1 Antibody Blocking Peptide - LS-E30329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KIAA1811 / BRSK1 Antibody Blocking Peptide - LS-E9552 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human BRSK1 Protein - H00084446-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BRSK1 Blocking Peptide - NBP1-77280PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

BRSK1 Blocking Peptide - NBP1-76778PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

BRSK1 Peptide - P3212 from Novus Biologicals Category Peptide Species Human

SAD1-BRSK1-Antibody-N-term-Blocking-peptide - BP8168a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BRSK1 Peptide - GTX85054-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

BRSK1 Peptide - GTX85055-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

BRSK1 - H00084446-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BRSK1 - H00084446-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BRSK1 - P5500 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

BRSK1 Control Peptide - AP30166CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BRSK1 Control Peptide - AP30167CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BRSK1 Peptide - 4081P from ProSci Category Peptide Species Human

BRSK1 Peptide - 4083P from ProSci Category Peptide Species Human

BRSK1 fusion protein - ag3357 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BRSK1, His-tagged - BRSK1-27740TH from Creative Biomart Category Protein Source E. coli

BrSK1 Protein, active, 250 µg - 14-675M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-675) and in bulk (cat#14-675-K) Source expressed by baculovirus in Sf21 cells

BrSK1 Protein, active, 10 µg - 14-675 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

Recombinant Human Serine/threonine-protein kinase BRSK1(BRSK1) - CSB-YP837438HU CSB-EP837438HU CSB-BP837438HU CSB-MP837438HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human BRSK1 His - CSI13389 from Cell Science Prices $615.00 Sizes 10 μg Species Human

BRSK1 Recombinant Protein Antigen - NBP2-38935PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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