BRSK1

Gene Symbol	BRSK1
Entrez Gene	84446
Alt Symbol	hSAD1
Species	Human
Gene Type	protein-coding
Description	BR serine/threonine kinase 1
Other Description	BR serine/threonine-protein kinase 1|SAD1 homolog|SAD1 kinase|SadB kinase short isoform|brain-selective kinase 1|brain-specific serine/threonine-protein kinase 1|protein kinase SAD1A|serine/threonine-protein kinase BRSK1|serine/threonine-protein kinase SAD-B|synapses of Amphids Defective homolog 1
Swissprots	Q96JL4 Q5J5B5 F1DG44 Q96AV4 Q8TDC3 Q8TDC2 Q8NDR4 Q8NDD0
Accessions	EAW72359 EAW72360 EAW72361 Q8TDC3 AB058714 BAB47440 AF479826 AAL87697 AF479827 AAL87698 AK124999 BAG54120 AL831945 CAD38595 AL834275 CAD38950 AY458602 AAS10354 AY505124 AAS86442 BC016681 AAH16681 HQ830199 ADX95745 XM_005259327 XP_005259384 XM_011527395 XP_011525697 XR_430213 NM_032430 NP_115806
Function	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma- tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, pro
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localizes to synaptic vesicles in neurons (By similarity). Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS- induced DNA damage. {ECO:0000250}.
Tissue Specificity	Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. {ECO:0000269|PubMed:15150265}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BRSK1 CRISPR/Cas9 KO Plasmid (h) - sc-408980 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 HDR Plasmid (h) - sc-408980-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 Double Nickase Plasmid (h) - sc-408980-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 Double Nickase Plasmid (h2) - sc-408980-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 CRISPR Activation Plasmid (h) - sc-408980-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 CRISPR Activation Plasmid (h2) - sc-408980-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 Lentiviral Activation Particles (h) - sc-408980-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 Lentiviral Activation Particles (h2) - sc-408980-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRSK1 siRNA (h) - sc-97540 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BRSK1 shRNA Plasmid (h) - sc-97540-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BRSK1 shRNA (h) Lentiviral Particles - sc-97540-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU132741 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0198 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0199 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0200 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN4072 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4072 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05480 from Sigma-Aldrich Category miRNA

BRSK1 siRNA (Human) - CRJ3478 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BRSK1 RNAi - H00084446-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

BRSK1 - MBS8223149 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BRSK1 (NM_032430.1) - SHH247866 from Creative biogene Category siRNA Species Reactivities Human

Human BRSK1 siRNA - orb273979 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BRSK1 shRNA Plasmid (Human) - CHJ3478 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BRSK1 miRNA 3'UTR clone - MiUTR1H-00953 from Creative biogene Species Reactivities Human

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