| Gene Symbol | BANF1 |
|---|---|
| Entrez Gene | 8815 |
| Alt Symbol | BAF, BCRP1, D14S1460, NGPS |
| Species | Human |
| Gene Type | protein-coding |
| Description | barrier to autointegration factor 1 |
| Other Description | barrier-to-autointegration factor|breakpoint cluster region protein 1 |
| Swissprots | O75531 Q6FGG7 O60558 |
| Accessions | EAW74483 EAW74484 EAW74485 EAW74486 O75531 AF044773 AAC08964 AF068235 AAD15901 AF070447 AAC23575 AK311961 BAG34901 BC005942 AAH05942 BC008705 BC107702 AAI07703 BG748852 BU940708 CR542140 CAG46937 NM_001143985 NP_001137457 NM_003860 NP_003851 |
| Function | Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:11005805, ECO:0000269|PubMed:12163470, ECO:0000269|PubMed:16680152}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16495336}. Cytoplasm {ECO:0000269|PubMed:16495336}. Chromosome {ECO:0000269|PubMed:16495336}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. May be included in HIV-1 virions via its interaction with viral GAG polyprotein. The phosphorylated form (by VRK1) shows a cytoplasmic localization. |
| Tissue Specificity | Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes. |