| Gene Symbol | THOC3 |
|---|---|
| Entrez Gene | 84321 |
| Alt Symbol | THO3, hTREX45 |
| Species | Human |
| Gene Type | protein-coding |
| Description | THO complex 3 |
| Other Description | TEX1 homolog|THO complex subunit 3 |
| Swissprots | Q6NZ53 Q96J01 |
| Accessions | EAW50534 Q96J01 AW511349 AW628745 BC006849 AAH06849 BC066325 AAH66325 BC068499 AAH68499 BG502664 BU634063 BU781626 HY009859 XM_011534666 XP_011532968 XM_011534667 XP_011532969 XM_011534668 XP_011532970 NM_032361 NP_115737 |
| Function | Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867}. |
| Subcellular Location | Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}. |
| Top Pathways | Spliceosome, RNA transport |
THOC3 293T Cell Transient Overexpression Lysate(Denatured) - H00084321-T01 from Acris Antibodies
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THOC3 293T Cell Transient Overexpression Lysate(Denatured) - H00084321-T02 from Acris Antibodies
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THOC3 overexpression lysate - LY403157 from Acris Antibodies
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THOC3 293 Cell Lysate - 402743 from ABBIOTEC
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THOC3 Overexpression Lysate (Denatured) - H00084321-T01 from Novus Biologicals
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THOC3 Overexpression Lysate (Native) - NBL1-16888 from Novus Biologicals
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THOC3 (h): 293 Lysate - sc-110698 from Santa Cruz Biotechnology
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THOC3 Over-expression Lysate Product - GWB-83E779 from Genway Biotech
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THOC3 Overexpression Lysate (Denatured) - H00084321-T02 from Novus Biologicals
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Panoply™ Human THOC3 Knockdown Stable Cell Line - CSC-DC015915 from Creative biogene
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Human THOC3 Knockout Cell Line-HeLa - CSC-RT1401 from Creative biogene
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THOC3 KO Cell Lysate-HeLa - CLKO-1253 from Creative biogene
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