THOC3

Gene Symbol THOC3
Entrez Gene 84321
Alt Symbol THO3, hTREX45
Species Human
Gene Type protein-coding
Description THO complex 3
Other Description TEX1 homolog|THO complex subunit 3
Swissprots Q6NZ53 Q96J01
Accessions EAW50534 Q96J01 AW511349 AW628745 BC006849 AAH06849 BC066325 AAH66325 BC068499 AAH68499 BG502664 BU634063 BU781626 HY009859 XM_011534666 XP_011532968 XM_011534667 XP_011532969 XM_011534668 XP_011532970 NM_032361 NP_115737
Function Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867}.
Subcellular Location Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.
Top Pathways Spliceosome, RNA transport

THOC3 (A-9) - sc-377456 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
THOC3 (A-9): sc-377456. Western blot analysis of THOC3 expression in non-transfected 293: sc-110760 (A), human THOC3 transfected 293: sc-110698 (B) and LADMAC (C) whole cell lysates.

THOC3 (N-20) - sc-66671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
THOC3 (N-20): sc-66671. Western blot analysis of THOC3 expression in non-transfected: sc-110760 (A) and human THOC3 transfected: sc-110698 (B) 293 whole cell lysates.

THOC3 (B-7) - sc-377067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
THOC3 (B-7): sc-377067. Western blot analysis of THOC3 expression in LADMAC whole cell lysate.

THOC3 (Z-22) - sc-134087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
THOC3 (Z-22): sc-134087. Western blot analysis of THOC3 expression in LADMAC whole cell lysate.

Anti-THOC3 antibody - ab89051 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-THOC3 antibody (ab89051) at 1/500 dilution + IMR-32 cell lysate at at 50 µg

Anti-THOC3 antibody - ab197089 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-THOC3 antibody (ab197089) at 1/500 dilutionLane 1 : MCF7 lysateLane 2 : HL-60 lysate

Anti-THOC3 antibody - ab21846 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-THOC3 antibody (ab21846) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ugLane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ugSecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-THOC3 antibody - N-terminal - ab173485 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-THOC3 antibody - N-terminal (ab173485) at 1/100 dilution + A2058 cell line lysate at 35 µg

Anti-THOC3 Antibody (C-Terminus) - LS-C110601 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
THOC3 antibody LS-C110601 Western blot of Fetal Spleen lysate.

Anti-THOC3 Antibody (aa71-98) - LS-C157192 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
THOC3 Antibody western blot of A2058 cell line lysates (35 ug/lane). The THOC3 antibody detected the THOC3 protein (arrow).

Anti-THOC3 Antibody (aa70-98, APC) - LS-C241773 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa70-98, Biotin) - LS-C241774 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa70-98, AP) - LS-C241775 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa70-98, FITC) - LS-C241777 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa70-98, PE) - LS-C241778 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa70-98, Azide-free, HRP) - LS-C247061 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa70-98) - LS-C325717 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC3 Antibody (aa151-200) - LS-C31568 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
THOC3 antibody LS-C31568 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

THOC3 Antibody - NBP1-92502 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: THOC3 Antibody [NBP1-92502] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

THOC3 Antibody - H00084321-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: THOC3 Antibody [H00084321-B01] - analysis of THOC3 expression in transfected 293T cell line by THOC3 MaxPab polyclonal antibody (B01). Lane 1: THOC3 transfected lysate (38.61 KDa). Lane 2: Non-transfected lysate.

THOC3 Antibody - NBP1-57297 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

THOC3 Antibody - H00084321-B02 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: THOC3 Antibody [H00084321-B02] - analysis of THOC3 expression in transfected 293T cell line by THOC3 MaxPab polyclonal antibody (B02). Lane 1: THOC3 transfected lysate (38.80 KDa). Lane 2: Non-transfected lysate.

THOC3 Antibody (3D4) - H00084321-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D4
Western Blot: THOC3 Antibody (3D4) [H00084321-M04] - Analysis of THOC3 expression in transfected 293T cell line by THOC3 monoclonal antibody (M04), clone 3D4. Lane 1: THOC3 transfected lysate (Predicted MW: 38.8 KDa). Lane 2: Non-transfected lysate.

Monoclonal Anti-THOC3 antibody produced in mouse - SAB1401888 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D4
<B>Immunoblotting</B><BR/>Monoclonal Anti-THOC3, antibody produced in mouse, clone 3D4, purified immunoglobulin: <B>Cat. No. SAB1401888</B>: Antibody concentration: 1.0 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-THOC3 antibody produced in rabbit - AV41052 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-THOC3: <B>Cat. No. AV41052</B>: Immunohistochemistry of THOC3 in Human Heart tissue with THOC3 antibody at 4-8 μg/mL.
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