THOC3

Gene Symbol	THOC3
Entrez Gene	84321
Alt Symbol	THO3, hTREX45
Species	Human
Gene Type	protein-coding
Description	THO complex 3
Other Description	TEX1 homolog|THO complex subunit 3
Swissprots	Q6NZ53 Q96J01
Accessions	EAW50534 Q96J01 AW511349 AW628745 BC006849 AAH06849 BC066325 AAH66325 BC068499 AAH68499 BG502664 BU634063 BU781626 HY009859 XM_011534666 XP_011532968 XM_011534667 XP_011532969 XM_011534668 XP_011532970 NM_032361 NP_115737
Function	Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867}.
Subcellular Location	Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.
Top Pathways	Spliceosome, RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

THOC3 Antibody Blocking Peptide - LS-E5362 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

THOC3 Antibody Blocking Peptide - LS-E15064 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

THOC3 Antibody Blocking Peptide - LS-E15065 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human THOC3 Protein - H00084321-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human THOC3 Protein - H00084321-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

THOC3-Antibody-N-term-Blocking-Peptide - BP17859a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

THOC3 Blocking Peptide - 33R-7013 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

THOC3 Blocking Peptide - 33R-5554 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

THOC3 - H00084321-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

THOC3 - H00084321-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

THOC3 - H00084321-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

THOC3 - H00084321-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

THOC3 fusion protein - Ag2289 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human THOC3, His-tagged - THOC3-29515TH from Creative Biomart Category Protein Source E. coli

Recombinant Human THOC3, GST-tagged - THOC3-3221H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human THO complex subunit 3(THOC3) - CSB-YP822232HU CSB-EP822232HU CSB-BP822232HU CSB-MP822232HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

THO complex subunit 3 (THOC3), Recombinant Protein - MBS1470068 from MyBioSource Category Protein Prices $1,115.00, $1,115.00, $1,345.00, $1,345.00, $1,765.00, $1,765.00, $2,230.00, $2,230.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

THOC3 Recombinant Protein Antigen - NBP1-92502PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

THOC3 Peptide, Human - M34GP15915H from Creative Peptides Category Peptide Source Synthetic. Species Human

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