Gene Symbol |
LIFR
|
Entrez Gene |
3977
|
Alt Symbol |
CD118, LIF-R, SJS2, STWS, SWS
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
leukemia inhibitory factor receptor alpha
|
Other Description |
CD118 antigen|LIF receptor|leukemia inhibitory factor receptor
|
Swissprots |
Q6LCD9 P42702
|
Accessions |
EAW55972 P42702 AK290059 BAF82748 AK308158 AK309882 BC141428 AAI41429 BC153096 AAI53097 BP219669 BQ008945 BX648635 DA835819 DA857408 U66563 AAB61897 X61615 CAA43805 XM_011514040 XP_011512342 XM_011514041 XP_011512343 XM_011514042 XP_011512344 NM_001127671 NP_001121143 NM_002310 NP_002301
|
Function |
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
|
Subcellular Location |
Isoform 1: Cell membrane; Single-pass type I membrane protein.
|
Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Signaling pathways regulating pluripotency of stem cells
|