Gene Symbol | LIFR |
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Entrez Gene | 3977 |
Alt Symbol | CD118, LIF-R, SJS2, STWS, SWS |
Species | Human |
Gene Type | protein-coding |
Description | leukemia inhibitory factor receptor alpha |
Other Description | CD118 antigen|LIF receptor|leukemia inhibitory factor receptor |
Swissprots | Q6LCD9 P42702 |
Accessions | EAW55972 P42702 AK290059 BAF82748 AK308158 AK309882 BC141428 AAI41429 BC153096 AAI53097 BP219669 BQ008945 BX648635 DA835819 DA857408 U66563 AAB61897 X61615 CAA43805 XM_011514040 XP_011512342 XM_011514041 XP_011512343 XM_011514042 XP_011512344 NM_001127671 NP_001121143 NM_002310 NP_002301 |
Function | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Signaling pathways regulating pluripotency of stem cells |
LIFR CRISPR/Cas9 KO Plasmid (h) - sc-400861 from Santa Cruz Biotechnology
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LIFR HDR Plasmid (h) - sc-400861-HDR from Santa Cruz Biotechnology
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LIFR Double Nickase Plasmid (h) - sc-400861-NIC from Santa Cruz Biotechnology
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LIFR Double Nickase Plasmid (h2) - sc-400861-NIC-2 from Santa Cruz Biotechnology
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LIFR CRISPR Activation Plasmid (h) - sc-400861-ACT from Santa Cruz Biotechnology
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LIFR CRISPR Activation Plasmid (h2) - sc-400861-ACT-2 from Santa Cruz Biotechnology
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LIFR Lentiviral Activation Particles (h) - sc-400861-LAC from Santa Cruz Biotechnology
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LIFR Lentiviral Activation Particles (h2) - sc-400861-LAC-2 from Santa Cruz Biotechnology
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LIFR siRNA (h) - sc-35808 from Santa Cruz Biotechnology
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LIFR shRNA Plasmid (h) - sc-35808-SH from Santa Cruz Biotechnology
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LIFR shRNA (h) Lentiviral Particles - sc-35808-V from Santa Cruz Biotechnology
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LIF R alpha RNAi - H00003977-R02 from Novus Biologicals
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MISSION® esiRNA - EHU009401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11702 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11702 from Sigma-Aldrich
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LIFR siRNA (Human) - CRH2691 from Cohesion Biosciences
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shRNA set against Human Lifr (NM_002310.5) - SHH330215 from Creative biogene
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Human LIFR siRNA - orb263193 from Biorbyt
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LIFR shRNA Plasmid (Human) - CHH2691 from Cohesion Biosciences
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