Gene Symbol | LIFR |
---|---|
Entrez Gene | 3977 |
Alt Symbol | CD118, LIF-R, SJS2, STWS, SWS |
Species | Human |
Gene Type | protein-coding |
Description | leukemia inhibitory factor receptor alpha |
Other Description | CD118 antigen|LIF receptor|leukemia inhibitory factor receptor |
Swissprots | Q6LCD9 P42702 |
Accessions | EAW55972 P42702 AK290059 BAF82748 AK308158 AK309882 BC141428 AAI41429 BC153096 AAI53097 BP219669 BQ008945 BX648635 DA835819 DA857408 U66563 AAB61897 X61615 CAA43805 XM_011514040 XP_011512342 XM_011514041 XP_011512343 XM_011514042 XP_011512344 NM_001127671 NP_001121143 NM_002310 NP_002301 |
Function | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Signaling pathways regulating pluripotency of stem cells |